INSERM, Unit 1033, LYOS, Lyon, France.
Université Claude Bernard Lyon 1, Lyon, France.
Br J Pharmacol. 2022 Nov;179(22):5036-5055. doi: 10.1111/bph.15402. Epub 2021 Apr 30.
Cysteinyl leukotrienes (CysLTs) are inflammatory lipid mediators that play a central role in the pathophysiology of several inflammatory diseases. Recently, there has been an increased interest in determining how these lipid mediators orchestrate tumour development and metastasis through promoting a pro-tumour micro-environment. Up-regulation of CysLTs receptors and CysLTs production is found in a number of cancers and has been associated with increased tumorigenesis. Understanding the molecular mechanisms underlying the role of CysLTs and their receptors in cancer progression will help investigate the potential of targeting CysLTs signalling for anti-cancer therapy. This review gives an overview of the biological effects of CysLTs and their receptors, along with current knowledge of their regulation and expression. It also provides a recent update on the molecular mechanisms that have been postulated to explain their role in tumorigenesis and on the potential of anti-CysLTs in the treatment of cancer.
半胱氨酰白三烯（CysLTs）是炎症性脂质介质，在多种炎症性疾病的病理生理学中发挥核心作用。最近，人们越来越关注这些脂质介质如何通过促进有利于肿瘤的微环境来协调肿瘤的发生和转移。在许多癌症中发现 CysLTs 受体和 CysLTs 的产生上调，并与肿瘤发生增加有关。了解 CysLTs 及其受体在癌症进展中的作用的分子机制将有助于研究针对 CysLTs 信号的潜在抗癌治疗方法。这篇综述概述了 CysLTs 及其受体的生物学效应，以及它们的调节和表达的现有知识。它还提供了最近关于其在肿瘤发生中的作用的分子机制的更新，以及抗 CysLTs 在癌症治疗中的潜力。
