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六氮杂镧(III)大环化合物的合成与光谱研究：具有混合型 G4 DNA 稳定作用。

Synthesis and Spectroscopic Investigation of a Hexaaza Lanthanum(III) Macrocycle with a Hybrid-Type G4 DNA Stabilizing Effect.

机构信息

Faculty of Chemistry, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 8, 61-614 Poznań, Poland.

Centre for Advanced Technology, Adam Mickiewicz University in Poznań, Uniwersytetu Poznańskiego 10, 61-614 Poznań, Poland.

出版信息

Inorg Chem. 2021 Feb 15;60(4):2122-2126. doi: 10.1021/acs.inorgchem.0c03260. Epub 2021 Feb 2.

DOI:10.1021/acs.inorgchem.0c03260
PMID:33528248
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7888264/
Abstract

Herein we present a mononuclear lanthanum(III) complex obtained in a template cyclocondensation reaction of lanthanum(III) nitrate salt, 1,2-propanediamine, and 2,6-diacetylpyridine ( complex). A preliminary investigation of the biological potential of this compound was conducted using a biomedically relevant target Tel26. We found that, different from parallel G4, antiparallel G4, and duplex DNA, only a hybrid-type G4 structure of Tel26 in a K solution was significantly stabilized by ≥7 °C, which emerged in our UV melting studies. Moreover, induced structural changes in the Tel26 structure in a K-deprived solution, suggesting that it may also lead to conformational changes in "non-G4" telomeric DNA.

摘要

在此，我们展示了一种单核镧（III）配合物，该配合物是通过镧（III）硝酸盐盐、1,2-丙二胺和 2,6-二乙酰吡啶（complex）的模板环缩合反应得到的。我们使用与生物医学相关的靶标 Tel26 对该化合物的生物潜力进行了初步研究。我们发现，与平行 G4、反平行 G4 和双链 DNA 不同，只有在 K 溶液中 Tel26 的杂交型 G4 结构在我们的 UV 融解研究中显著稳定，升温≥7°C。此外，它诱导了 Tel26 结构在 K 缺乏溶液中的结构变化，表明它也可能导致“非 G4”端粒 DNA 的构象变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a97/7888264/4d85418cd09c/ic0c03260_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a97/7888264/f8eaa6a8195c/ic0c03260_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a97/7888264/0e85552e52cf/ic0c03260_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a97/7888264/c8cfe2de1051/ic0c03260_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a97/7888264/d128566e6d74/ic0c03260_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a97/7888264/4d85418cd09c/ic0c03260_0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a97/7888264/f8eaa6a8195c/ic0c03260_0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a97/7888264/0e85552e52cf/ic0c03260_0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a97/7888264/c8cfe2de1051/ic0c03260_0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a97/7888264/d128566e6d74/ic0c03260_0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1a97/7888264/4d85418cd09c/ic0c03260_0004.jpg

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