Okuyama S, Aihara H
Research Center, Taisho Pharmaceutical Co. Ltd, Saitama, Japan.
Neuropharmacology. 1988 Jan;27(1):67-72. doi: 10.1016/0028-3908(88)90202-x.
The effects of nootropic drugs and related compounds on transcallosal responses were examined in urethane-anesthetized rats. The transcallosal response was recorded from the surface of the anterior neocortex following electrical stimulation of the contralateral corpus callosum. The transcallosal response consisted of a biphasic positive-negative waveform. Hopantenate increased the amplitude of the positive- and negative-waves, without affecting the latency. Aniracetam, idebenone, bifemelane hydrochloride, TRH and meclofenoxate increased the amplitude of the negative-wave, without affecting the latencies. Vinpocetine and eburunamonine had no effect on the transcallosal response. Muscimol, amino-oxyacetic acid, diazepam and pentobarbital increased the amplitude of the positive-wave and decreased the amplitude of the negative-wave, without affecting the latencies. Bicuculline and picrotoxin increased the amplitude of the negative-wave, without affecting the latencies. Physostigmine decreased the amplitude of the negative-wave, without affecting the latency. Atropine was without effect. The pharmacological nature of the transcallosal response is discussed, based on findings with 16 different pharmacological agents.
在乌拉坦麻醉的大鼠中研究了益智药及相关化合物对胼胝体反应的影响。在对侧胼胝体进行电刺激后，从前额叶新皮质表面记录胼胝体反应。胼胝体反应由正负双相波形组成。霍帕酯增加了正波和负波的振幅，而不影响潜伏期。茴拉西坦、艾地苯醌、盐酸比呋内酰胺、促甲状腺激素和甲氯芬酯增加了负波的振幅，而不影响潜伏期。长春西汀和依布劳氨宁对胼胝体反应无影响。蝇蕈醇、氨基氧乙酸、地西泮和戊巴比妥增加了正波的振幅，降低了负波的振幅，而不影响潜伏期。荷包牡丹碱和印防己毒素增加了负波的振幅，而不影响潜伏期。毒扁豆碱降低了负波的振幅，而不影响潜伏期。阿托品无作用。基于16种不同药理剂的研究结果，讨论了胼胝体反应的药理学性质。
