Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
Department of Small Animal Clinical Sciences, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, Texas, USA.
J Vet Intern Med. 2021 Mar;35(2):912-924. doi: 10.1111/jvim.16021. Epub 2021 Feb 2.
Annual wellness testing is widely recommended for apparently healthy dogs, but there is little data to assist with distinguishing normal variation from clinically important changes.
To define variability in biochemistry analytes between annual wellness tests in healthy Golden Retrievers.
Four hundred thirty-four Golden Retrievers undergoing annual health assessments by their primary care veterinarians as part of a prospective cohort study.
Changes in 23 biochemistry analytes were calculated between year 1 and year 2 health checks for 196 dogs classified as healthy for ≥3 consecutive years. Using a direct nonparametric method, annual change intervals were constructed to define normal variability. A validation cohort of 238 dogs without a diagnosis of systemic disease for ≥3 consecutive years were compared with the reference and annual change intervals, and the proportions of dogs outside annual change intervals and a population-based reference interval were compared by using a McNemar test.
Annual change intervals were calculated based on 190 dogs after outlier removal. For all 23 analytes, >90% of dogs in the validation cohort were within the annual change interval. There were no significant differences in the classification by reference versus annual change intervals.
The annual change intervals met performance requirements for classification of dogs that did not develop systemic disease in the year following wellness testing as normal.
年度健康体检被广泛推荐用于看似健康的犬只，但目前几乎没有数据可以帮助区分正常变化与具有临床意义的变化。
确定健康金毛寻回猎犬年度健康检查中生化指标的变化。
434 只金毛寻回猎犬，它们的初级保健兽医在一项前瞻性队列研究中对其进行年度健康评估。
对 196 只连续 3 年以上被诊断为健康的犬只进行了第 1 年和第 2 年健康检查之间 23 项生化指标的变化计算。使用直接非参数方法，构建了年度变化间隔来定义正常的变异性。将 238 只连续 3 年以上没有系统性疾病诊断的犬只作为验证队列与参考和年度变化间隔进行比较，并使用 McNemar 检验比较了犬只在年度变化间隔和基于人群的参考间隔之外的比例。
在去除异常值后，基于 190 只犬计算了年度变化间隔。对于所有 23 项分析物，验证队列中>90%的犬在年度变化间隔内。参考和年度变化间隔的分类无显著差异。
年度变化间隔满足了以下要求：将在健康检查后的一年中未发展为系统性疾病的犬只分类为正常。
