Ober K P, Kelly D L
Department of Medicine, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, North Carolina.
Neurosurgery. 1988 Feb;22(2):386-7. doi: 10.1227/00006123-198802000-00019.
A 42-year-old man with severe testicular failure (testosterone 24 ng/dl, normal 300-1100) was found to have a nonfunctioning chromophobe pituitary adenoma. Resection of the pituitary tumor resulted in recovery of gonadal function (testosterone 359 ng/dl). Hypogonadism caused by pituitary adenomas is usually attributed to either hyperprolactinemia or irreversible destruction of normal pituitary tissue, neither of which is applicable to this patient. The recovery of our patient's gonadal function after operation suggests that a reversible compression of viable tissue or impairment of hypothalamic-pituitary communications was responsible for his endocrine deficiency.
一名42岁患有严重睾丸功能衰竭的男性（睾酮水平为24 ng/dl，正常范围为300 - 1100）被发现患有无功能的嫌色细胞垂体腺瘤。垂体肿瘤切除后，性腺功能得以恢复（睾酮水平为359 ng/dl）。垂体腺瘤导致的性腺功能减退通常归因于高催乳素血症或正常垂体组织的不可逆破坏，但这两种情况都不适用于该患者。我们的患者术后性腺功能的恢复表明，存活组织的可逆性受压或下丘脑 - 垂体通讯受损是其内分泌不足的原因。
