Faculty of Medical Sciences, The University of the West Indies (Cave Hill), Barbados.
The Queen Elizabeth Hospital, Bridgetown St. Michael, Barbados;
Allergol Immunopathol (Madr). 2021 Jan 2;49(1):17-24. doi: 10.15586/aei.v49i1.21. eCollection 2021.
The main objective was to determine the prevalence of recurrent wheezing (RW) among infants and toddlers as well as the prevalence of asthma predictive risk factors among those with RW.
A prospective study of a cohort of babies recruited after their birth during July 2015-June 2017. Mothers were contacted using the WhatsApp messaging system for digital follow-up on their baby's condition at 3-monthly intervals until they were 18 months old. Information on wheezing and its correlates were collected by digital follow-up and corroborated at an in-person interview and examination of their baby at 18 months of age. Recurrent wheezing was defined as more than three episodes of wheezing or its correlates during the follow-up period.
There were 338 males (41.5%) and 476 (58.5%) females. Overall, 31.1% (95% CI = 27.9%, 34.4%) had RW by 18 months and the same number had RW during their first year of life. Of the infants with RW, 121 (47.8%; 95% CI = 41.6, 54.2) had at least one or both of the major criteria and/or at least two minor criteria of the stringent Asthma Predictive Index (API). Of those with RW, 32.0% received antihistamine and 20% had received antibiotics on their last visit to a physician for wheezing or symptoms of cough, cold, and/or breathing difficulty.
Nearly a third of infants and toddlers had RW and nearly half of the infants with RW had risk factors fulfilling the criteria of the stringent API.
主要目的是确定婴儿和幼儿反复喘息（RW）的患病率，以及 RW 患儿中哮喘预测风险因素的患病率。
这是一项前瞻性队列研究，于 2015 年 7 月至 2017 年 6 月期间在婴儿出生后招募了一组婴儿。通过 WhatsApp 消息系统联系母亲，以每 3 个月一次的频率对婴儿的情况进行数字随访，直到他们 18 个月大。通过数字随访收集喘息及其相关信息，并在 18 个月龄时通过面对面访谈和婴儿体检进行核实。反复喘息定义为随访期间喘息或其相关症状发作超过 3 次。
共有 338 名男性（41.5%）和 476 名女性（58.5%）。总体而言，18 个月时有 31.1%（95%CI=27.9%，34.4%）发生 RW，同样数量的婴儿在其生命的第一年发生 RW。在有 RW 的婴儿中，121 名（47.8%；95%CI=41.6，54.2）至少有一个或两个严格哮喘预测指数（API）的主要标准和/或至少两个次要标准。在有 RW 的婴儿中，32.0%在最近一次因喘息或咳嗽、感冒和/或呼吸困难症状就诊时接受了抗组胺药治疗，20%接受了抗生素治疗。
近三分之一的婴儿和幼儿有 RW，近一半的 RW 患儿有符合严格 API 标准的风险因素。
