Browne T R, Szabo G K, Evans J, Evans B A, Greenblatt D J, Mikati M A
Department of Neurology, Boston University School of Medicine, MA.
Neurology. 1988 Apr;38(4):639-42. doi: 10.1212/wnl.38.4.639.
Phenytoin pharmacokinetics and biotransformation were studied with stable isotope tracer techniques in six patients before and after addition of phenobarbital. No significant (p less than 0.05) changes in phenytoin serum concentration, clearance, elimination half-life, volume of distribution, or clearance via production of p-hydroxyphenyl-phenylhydantoin or phenytoin dihydrodiol occurred after addition of phenobarbital. Thus, frequent phenytoin serum concentration determinations or a change in phenytoin dosing rate are probably not necessary after adding phenobarbital.
采用稳定同位素示踪技术，在6例患者加用苯巴比妥前后研究了苯妥英的药代动力学和生物转化。加用苯巴比妥后，苯妥英的血清浓度、清除率、消除半衰期、分布容积，或经对羟基苯基苯妥英或苯妥英二氢二醇生成途径的清除率，均未发生显著（p<0.05）变化。因此，加用苯巴比妥后，可能无需频繁测定苯妥英血清浓度或改变苯妥英给药速率。
