Bethune Hospital Affiliated to Shanxi Medical University, PR China.
Department of Rheumatology, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, PR China.
Int Immunopharmacol. 2021 Apr;93:107392. doi: 10.1016/j.intimp.2021.107392. Epub 2021 Jan 30.
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that mainly affects synovial joints. During the course of RA, the synovium transforms into hyperplastic invasive tissue, leading to cartilage and bone destruction. Fibroblast-like synoviocytes (FLS) in the synovial lining develop aggressive phenotypes and produce pathogenic mediators that lead to the occurrence and progression of disease, playing a major role in RA pathophysiology. Therefore, research on FLS has become the main focus within the RA field. With technical advances and the development of multi-omics comprehensive analysis approaches, it has become possible to identify different FLS subsets via high-throughput sequencing and investigate differences between FLS phenotypes, allowing for the detailed study of RA pathogenesis. This review summarizes recent works on FLS subtypes and the surface marker proteins identified for different subtypes, providing a theoretical basis and reference for future studies on FLS in RA. The current work also addresses the clinical potential of FLS surface markers in RA based on related research from other fields.
类风湿关节炎（RA）是一种主要影响滑膜关节的慢性系统性自身免疫性疾病。在 RA 病程中，滑膜转化为增生性侵袭性组织，导致软骨和骨破坏。滑膜衬里中的成纤维样滑膜细胞（FLS）表现出侵袭性表型，并产生导致疾病发生和进展的致病介质，在 RA 病理生理学中起主要作用。因此，FLS 的研究已成为 RA 领域的主要关注点。随着技术的进步和多组学综合分析方法的发展，通过高通量测序已经可以识别不同的 FLS 亚群，并研究 FLS 表型之间的差异，从而可以详细研究 RA 的发病机制。本综述总结了 FLS 亚型的最新研究进展以及不同亚型鉴定的表面标记蛋白，为 RA 中 FLS 的未来研究提供了理论依据和参考。目前的工作还根据其他领域的相关研究，探讨了 FLS 表面标记物在 RA 中的临床潜力。
