抗癫痫药物、癫痫发作的发生以及潜在降低癫痫发作阈值的精神药物合用对癫痫合并智力障碍成人的影响。
Antiepileptic drugs, occurrence of seizures and effect of co-administration of potential seizure threshold-lowering psychotropic drugs in adults with intellectual disability who have epilepsy.
机构信息
School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin, Dublin, Ireland.
The Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing (IDS-TILDA), School of Nursing & Midwifery, Trinity College Dublin, Dublin, Ireland.
出版信息
J Appl Res Intellect Disabil. 2021 May;34(3):818-829. doi: 10.1111/jar.12857. Epub 2021 Feb 2.
BACKGROUND
This study explored antiepileptic drug use, frequency of seizures, and the effect of psychotropic drugs with the potential to lower the seizure threshold in persons diagnosed with epilepsy and intellectual disability.
METHODS
Data for this study were drawn from Wave 3 of the Intellectual Disability Supplement to the Irish Longitudinal Study on Ageing (IDS-TILDA). Psychotropic drugs were categorised for potential seizure threshold-lowering risk (low, moderate, high). Binary logistic regression was performed to identify factors associated with seizure frequency.
RESULTS
Epilepsy prevalence was 35.8% (n = 196), of which 57.7% reported a mental health condition. Participants with seizure data classified as taking at least one moderate-/high-risk medication were significantly less likely to experience a seizure compared to participants taking no potential seizure threshold-lowering medication.
CONCLUSIONS
Psychotropic drugs recommended to be avoided or used with caution did not provoke increased seizure frequency in this cohort.
背景
本研究探讨了癫痫和智力障碍患者抗癫痫药物的使用、癫痫发作频率以及具有降低癫痫发作阈值潜力的精神药物的影响。
方法
本研究的数据来自爱尔兰老龄化纵向研究（IDS-TILDA）智力障碍增刊的第 3 波。精神药物被分为具有潜在降低癫痫发作阈值风险的药物（低、中、高）。采用二元逻辑回归分析确定与癫痫发作频率相关的因素。
结果
癫痫患病率为 35.8%（n=196），其中 57.7%的人报告有心理健康状况。与服用无潜在降低癫痫发作阈值药物的参与者相比，有癫痫发作数据的参与者服用至少一种中/高风险药物的情况下，癫痫发作的可能性显著降低。
结论
在本队列中，建议避免或谨慎使用的精神药物并没有引起癫痫发作频率增加。
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