Department of Ultrasound, Liaocheng People's Hospital.
Department of Ultrasound, Gaotang County People's Hospital, Liaocheng, Shandong Province, China.
Medicine (Baltimore). 2021 Jan 29;100(4):e23905. doi: 10.1097/MD.0000000000023905.
Papillary thyroid microcarcinoma is easy to be missed because of its small focus, concealed incidence and lack of clinical features. Ultrasound examination is one of the main methods for the detection and diagnosis of papillary thyroid microcarcinoma. The detection rate of conventional ultrasound is not ideal. Combined ultrasound elastography can improve the detection rate, but there is lack of evidence-based evidence. The purpose of this study was to systematically evaluate the value of conventional ultrasound combined with ultrasound elastography in the diagnosis of papillary thyroid microcarcinoma.
A systematic search was performed by retrieving on English databases (PubMed, Embase, Web of Science, the Cochrane Library) and Chinese databases (CNKI, Wanfang, Weipu (VIP), CBM). The retrieval time limit was from the establishment of the database to November 2020 and manually search for the conventional ultrasound combined with ultrasound elastography in the diagnosis of papillary thyroid microcarcinoma. Two researchers extracted and evaluated the quality of the data in the included study independently. A meta-analysis was performed using Meta Disc1.4 and RevMan5.3 software.
This study will evaluate the accuracy and practicability of conventional ultrasound combined with ultrasonic elastography in the diagnosis of papillary thyroid microcarcinoma, and provide evidence-based basis for clinicians to choose the appropriate or best diagnostic method.
The private information from individuals will not be published. This systematic review also will not involve endangering participant rights. Ethical approval is not required.
DOI: 10.17605 / OSF.IO / V6HK7.
由于甲状腺微小乳头状癌病灶小、隐匿性发病、缺乏临床特征，易被漏诊。超声检查是发现和诊断甲状腺微小乳头状癌的主要方法之一，常规超声的检出率不理想，联合超声弹性成像技术可提高检出率，但缺乏循证医学证据。本研究旨在系统评价常规超声联合超声弹性成像技术在甲状腺微小乳头状癌诊断中的应用价值。
计算机检索英文数据库（PubMed、Embase、Web of Science、the Cochrane Library）和中文数据库（CNKI、万方、维普、中国生物医学文献数据库），检索时间从数据库建立至 2020 年 11 月，同时辅以手工检索，收集常规超声联合超声弹性成像技术诊断甲状腺微小乳头状癌的研究。由 2 位研究者独立提取和评价纳入研究的质量后，采用 Meta Disc1.4 及 RevMan5.3 软件进行 Meta 分析。
本研究将系统评价常规超声联合超声弹性成像技术在甲状腺微小乳头状癌诊断中的准确性和实用性，为临床医师选择合适或最佳的诊断方法提供循证医学依据。
本研究不涉及个体的隐私信息，也不会对研究对象的权益造成危害，无需伦理审批。
OSF 注册号：DOI：10.17605/OSF.IO/V6HK7。
