Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA
Toxic Rep Ser. 2017 Aug(85). doi: 10.22427/NTP-TOX-85.
Tetrabromobisphenol A-bis(2,3-dibromopropyl ether) is used as a flame retardant in electronics, building and construction materials, and automotive materials. Tetrabromobisphenol A-bis(2,3-dibromopropyl ether) was nominated for toxicology and in vivo genotoxicity study by the National Institute of Environmental Health Sciences because, although human exposure potential may be low, there was concern that this chemical has carcinogenic potential and has not been adequately studied. The compound was also selected for study because dibromo-1-propanol (the core structure of the 2,3-dibromopropyl ether side chain) has been studied by the NTP and found to be carcinogenic. Male and female F344/NTac rats and B6C3F1/N mice were administered tetrabromobisphenol A-bis(2,3-dibromopropyl ether) (approximately 94% pure) in corn oil by gavage for 3 months. Genetic toxicology studies were conducted in Salmonella typhimurium and mouse peripheral blood erythrocytes. (Abstract Abridged).
四溴双酚A - 双（2,3 - 二溴丙基醚）被用作电子、建筑和建筑材料以及汽车材料中的阻燃剂。美国国家环境卫生科学研究所提名四溴双酚A - 双（2,3 - 二溴丙基醚）进行毒理学和体内遗传毒性研究，原因是尽管人类接触该物质的可能性可能较低，但人们担心这种化学物质具有致癌潜力且尚未得到充分研究。选择该化合物进行研究还因为二溴 - 1 - 丙醇（2,3 - 二溴丙基醚侧链的核心结构）已由美国国家毒理学计划进行研究并发现具有致癌性。将雄性和雌性F344/NTac大鼠和B6C3F1/N小鼠通过灌胃给予玉米油中的四溴双酚A - 双（2,3 - 二溴丙基醚）（纯度约为94%），持续3个月。在鼠伤寒沙门氏菌和小鼠外周血红细胞中进行了遗传毒理学研究。（摘要节略）
