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N Engl J Med. 2018 Aug 9;379(6):504-506. doi: 10.1056/NEJMp1803661.
3
Parenteral Opioid Shortage - Treating Pain during the Opioid-Overdose Epidemic.胃肠外阿片类药物短缺——在阿片类药物过量流行期间治疗疼痛。
N Engl J Med. 2018 Aug 16;379(7):601-603. doi: 10.1056/NEJMp1807117. Epub 2018 Jul 18.
4
Prospective Evaluation of an Opioid Reduction Protocol in Hand Surgery.手部手术中阿片类药物减量方案的前瞻性评估
J Hand Surg Am. 2018 Jun;43(6):516-522.e1. doi: 10.1016/j.jhsa.2018.01.021. Epub 2018 Mar 12.
5
The Public and the Opioid-Abuse Epidemic.公众与阿片类药物滥用流行问题
N Engl J Med. 2018 Feb 1;378(5):407-411. doi: 10.1056/NEJMp1714529. Epub 2018 Jan 3.
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7
Leading the Way to Solutions to the Opioid Epidemic: AOA Critical Issues.引领阿片类药物流行解决方案之路:美国骨科医师学会关键问题。
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Impact of prescription drug monitoring programs (PDMPs) on opioid utilization among Medicare beneficiaries in 10 US States.10 个美国州的医疗保险受益人中处方药物监测计划(PDMP)对阿片类药物使用的影响。
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阿片类药物限制立法对手外科患者有效吗?

Is Opioid-Limiting Legislation Effective for Hand Surgery Patients?

机构信息

Brown University, Providence, RI, USA.

出版信息

Hand (N Y). 2022 Nov;17(6):1139-1146. doi: 10.1177/1558944720988132. Epub 2021 Feb 3.

DOI:10.1177/1558944720988132
PMID:33530762
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9608291/
Abstract

BACKGROUND

The Rhode Island State Legislature passed the in 2016 to limit opioid prescriptions. We aimed to objectively evaluate its effect on opioid prescribing for hand surgery patients and also identify risk factors for prolonged opioid use.

METHODS

A 6-month period (January-June 2016) prior to passage of the law was compared with a period following its implementation (July-December 2017). Thumb carpometacarpal arthroplasty and distal radius fracture fixation were classified as "major surgery" and carpal tunnel and trigger finger release as "minor surgery." Prescription Drug Monitoring Database was used to review controlled substances filled during the study periods.

RESULTS

A total of 1380 patients met our inclusion criteria, with 644 and 736 . Patients undergoing "major surgery" saw a significant decrease in the number of pills issued in the first postoperative prescription (41.1 vs 21.0) and a corresponding decrease in morphine milligram equivalents (MMEs) (318.6 vs 159.2 MMEs) after implementation. A 30% decrease in MMEs was also seen in those undergoing "major surgery" in the first 30 days postoperatively (544.7 vs 381.7 MMEs). Risk factors for prolonged opioid use included male sex and preoperative opioid use.

CONCLUSIONS

In Rhode Island, opioid-limiting legislation resulted in a significant decrease in the number of pills and MMEs of the initial prescription and a 30% decrease in total MMEs in the 30-day postoperative period after "major hand surgery." Additional research is needed to explore the association between legislation and clinical outcomes.

摘要

背景

2016 年,罗得岛州立法机构通过了 法案,以限制阿片类药物的处方。我们旨在客观评估该法案对手部手术患者阿片类药物处方的影响,并确定延长阿片类药物使用的风险因素。

方法

在该法案通过之前的 6 个月(2016 年 1 月至 6 月)与实施之后的 6 个月(2017 年 7 月至 12 月)进行比较。拇指腕掌关节置换术和桡骨远端骨折固定术被归类为“大手术”,而腕管松解术和扳机指松解术被归类为“小手术”。处方药物监测数据库用于审查研究期间开具的受控物质。

结果

共有 1380 名患者符合纳入标准,其中 644 名为 ,736 名为 。接受“大手术”的患者,术后第一份处方的药丸数量显著减少(41.1 片比 21.0 片),相应的吗啡毫克当量(MME)减少(318.6 毫克当量比 159.2 毫克当量)。接受“大手术”的患者在术后 30 天内 MME 也减少了 30%(544.7 毫克当量比 381.7 毫克当量)。延长阿片类药物使用的风险因素包括男性和术前阿片类药物使用。

结论

在罗得岛州,限制阿片类药物的立法导致“大手部手术”后初始处方的药丸数量和 MME 显著减少,以及术后 30 天内总 MME 减少 30%。需要进一步研究立法与临床结果之间的关联。