Li Hao, He Zhongnan, Yang Qianwen, Wang Jiaming, Ling Yan
Department of General Surgery, The First People's Hospital of Anqing Anqing, Anhui, China.
Department of Thyroid and Breast Surgery, Hezhou People's Hospital Hezhou, Guangxi, China.
Int J Clin Exp Pathol. 2021 Jan 1;14(1):24-33. eCollection 2021.
To analyze factors that affect the prognosis of triple-negative breast cancer patients under 35 years old.
We retrospectively analyzed confirmed triple-negative breast cancer cases from 2000 to 2016 in multiple institutions. A total of 105 patients were included in the study, Nineteen of them were diagnosed with age ≤ 25, and 86 of them were aged between 26 to 35.
There were no statistically significant differences in clinicopathologic features and treatment choices between patients aged ≤ 25 years and those aged 26-35 years (P > 0.05). Survival analysis showed no statistically significant differences in DFS and OS between the two groups (P > 0.05). Multiple factor analysis showed that age of menarche (HR 0.697, 95% CI [0.5634, 0.8631]), pregnancy correlation (HR 2.673, 95% CI [1.1581, 6.1741]), and lymph node positivity (HR 4.915, 95% CI [2.3774, 10.1627]) were independent prognostic factors that affected patients' DFS. Independent prognostic factors that influenced OS were age of menarche (HR 0.598, 95% CI [0.462 6, 0.775]) and lymph node positivity (HR 7.751, 95% CI [2.923, 20.559]).
There was no difference in the clinicopathological features and prognosis between women ≤ 25 and women aged 26-35 years with triple-negative breast cancer. Age of menarche, pregnancy correlation, and positive lymph nodes were independent factors affecting prognosis. The relationship between reproductive factors and prognosis in young patients with triple-negative breast cancer needs further discussion.
分析影响35岁以下三阴性乳腺癌患者预后的因素。
我们回顾性分析了2000年至2016年多家机构确诊的三阴性乳腺癌病例。本研究共纳入105例患者，其中19例诊断时年龄≤25岁，86例年龄在26至35岁之间。
年龄≤25岁的患者与年龄在26 - 35岁的患者在临床病理特征和治疗选择上无统计学显著差异（P>0.05）。生存分析显示两组间无病生存期（DFS）和总生存期（OS）无统计学显著差异（P>0.05）。多因素分析显示，初潮年龄（HR 0.697，95%可信区间[0.5634, 0.8631]）、妊娠相关性（HR 2.673，95%可信区间[1.1581, 6.1741]）和淋巴结阳性（HR 4.915，95%可信区间[2.3774, 10.1627]）是影响患者DFS的独立预后因素。影响OS的独立预后因素是初潮年龄（HR 0.598，95%可信区间[0.462 6, 0.775]）和淋巴结阳性（HR 7.751，95%可信区间[2.923, 20.559]）。
年龄≤25岁的三阴性乳腺癌女性与年龄在26 - 35岁的女性在临床病理特征和预后方面无差异。初潮年龄、妊娠相关性和淋巴结阳性是影响预后的独立因素。年轻三阴性乳腺癌患者生殖因素与预后的关系有待进一步探讨。
