囊性纤维化中的性别差异：关于女性性激素对肺部病理生理学及预后影响的综述
Sex disparities in cystic fibrosis: review on the effect of female sex hormones on lung pathophysiology and outcomes.
作者信息
Lam Grace Y, Goodwin Jodi, Wilcox Pearce G, Quon Bradley S
机构信息
Centre for Heart Lung Innovation, St Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.
Adult Cystic Fibrosis Program, St Paul's Hospital, Vancouver, BC, Canada.
出版信息
ERJ Open Res. 2021 Jan 18;7(1). doi: 10.1183/23120541.00475-2020. eCollection 2021 Jan.
Sex differences in morbidity and mortality have been reported in the cystic fibrosis (CF) population worldwide. However, it is unclear why CF women have worse clinical outcomes than men. In this review, we focus on the influence of female sex hormones on CF pulmonary outcomes and summarise data from and experiments on how oestrogen and progesterone might modify mucociliary clearance, immunity and infection in the CF airways. The potential for novel sex hormone-related therapeutic interventions is also discussed.
全球囊性纤维化（CF）患者群体中已报告了发病率和死亡率的性别差异。然而，尚不清楚为何CF女性的临床结局比男性更差。在本综述中，我们重点关注女性性激素对CF肺部结局的影响，并总结来自[具体实验]的实验数据，探讨雌激素和孕激素如何改变CF气道中的黏液纤毛清除功能、免疫力和感染情况。我们还讨论了新型性激素相关治疗干预措施的可能性。
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