Eliyahu Efrat, Katz Michael G, Vincek Adam, Freage-Kahn Lina, Ravvin Shana, Tal Smadar, Grage Henry, Shtraizent Nataly, Barak Tuvia, Arkush Bezalel
Aveta.Life, Hoboken, NJ, USA.
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 1470 Madison Ave, Box 1030, New York, NY, 10029-6574, USA.
Pulm Ther. 2023 Dec;9(4):461-477. doi: 10.1007/s41030-023-00240-0. Epub 2023 Oct 10.
This review provides an overview of menopausal hormone therapy and pulmonary disease risk, with a focus on the effect of hormone replacement therapy (HRT) on pulmonary function and its relation to lung diseases. This summary is based on authors' knowledge in the field of HRT and supplemented by a PubMed search using the terms "menopause hormone therapy," "asthma", "lung cancer", "chronic obstructive pulmonary disease", "lung function", and "pulmonary hypertension". Available evidence indicates that there is limited research on the role of sex hormones in the susceptibility, severity, and progression of chronic respiratory diseases. However, some studies suggest that the hormonal changes that occur during the menopausal transition may have an impact on pulmonary function and respiratory diseases. Women are in need of convenient access to a safe and effective modality for personalized HRT based on an artificial intelligence (AI)-driven platform that will enable them to receive personalized hormonal treatment through frequent, convenient, and accurate measurements of hormone levels in peripheral blood.
本综述概述了更年期激素治疗与肺部疾病风险，重点关注激素替代疗法（HRT）对肺功能的影响及其与肺部疾病的关系。本综述基于作者在HRT领域的知识，并通过使用“更年期激素治疗”、“哮喘”、“肺癌”、“慢性阻塞性肺疾病”、“肺功能”和“肺动脉高压”等术语在PubMed上进行检索加以补充。现有证据表明，关于性激素在慢性呼吸道疾病易感性、严重程度和进展中的作用的研究有限。然而，一些研究表明，更年期过渡期间发生的激素变化可能会对肺功能和呼吸道疾病产生影响。女性需要通过基于人工智能（AI）驱动平台的安全有效的个性化HRT模式，以便她们能够通过频繁、便捷和准确地测量外周血中的激素水平来接受个性化激素治疗。
