朝藿定 C 对阿尔茨海默病 APP/PSI 转基因小鼠学习记忆的影响。
Effects of Phenylethanoid Glycosides Extracted from on the Learning and Memory of the APP/PSI Transgenic Mice with Alzheimer's Disease.
机构信息
Department of Pharmacy, The First Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, China.
College of Pharmacy, Xinjiang Medical University, Urumqi 830011, China.
出版信息
Biomed Res Int. 2021 Jan 18;2021:1291549. doi: 10.1155/2021/1291549. eCollection 2021.
BACKGROUND
To investigate the effects of phenylethanoid glycosides (PhGs) extracted from on the behavioral and cognition capacity of the APP/PSI transgenic mice with Alzheimer's disease (AD).
METHODS
AD mice were randomly divided into the control group, model group, donepezil group, PhG groups, and verbascose group, respectively. Three weeks later, the animals were subject to behavioral and cognition evaluation by the nesting test, Morris water maze test, and step-down test.
RESULTS
The cognition capacity in these groups showed a significant increase compared with that in the model group. The step-down test indicated that the errors induced by the memory decrease in the PhG groups and verbascose group showed a significant decrease compared with those in the model group ( < 0.05).
CONCLUSIONS
PhGs attenuated the cognitive dysfunction features of the APP/PSI transgenic gene. Besides, PhGs were the active components for the anti-AD activity of . .
背景
研究从地黄中提取的苯乙醇苷（PhGs）对阿尔茨海默病（AD）APP/PSI 转基因小鼠行为和认知能力的影响。
方法
AD 小鼠随机分为对照组、模型组、多奈哌齐组、PhG 组和毛蕊花糖苷组，分别给药 3 周后，通过嵌合体试验、Morris 水迷宫试验和跳台试验进行行为和认知能力评价。
结果
与模型组相比，这些组的认知能力均显著提高。跳台试验表明，PhG 组和毛蕊花糖苷组因记忆减退而导致的错误明显减少（<0.05）。
结论
PhGs 可减轻 APP/PSI 转基因基因小鼠的认知功能障碍特征。此外，PhGs 是地黄抗 AD 活性的有效成分。
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