Shi Rou, Lin Chunwen, Hong Yaping, Xia Xiaoying, Chen Yingjian, Li Shu, Xiu Liangchang
Department of Epidemiology and Medical Statistics, School of Public Health, Guangdong Medical University, Dongguan, Guangdong 523808, China.
Huizhou Municipal Central Hospital, Huizhou, Guangdong 516008, China.
Biomed Res Int. 2021 Jan 19;2021:8868339. doi: 10.1155/2021/8868339. eCollection 2021.
Free triiodothyronine (FT3) is an independent risk factor for nonalcoholic fatty liver disease (NAFLD) in patients with euthyroid. However, whether FT3 has an independent effect on NAFLD in a population of type 2 diabetes remains unknown. The purpose of this study was to identify the potential role of FT3 in NAFLD with T2DM.
A cross-sectional study. . A total of 859 T2DM patients who met the inclusion criteria were included. There were 506 T2DM patients without NAFLD and 353 T2DM patients with NAFLD.
The independent samples -test or Wilcoxon rank sum test were used for continuous variables of different distribution types, while the chi-square test was used for categorical variables. Pearson correlation analysis and linear regression were used to analyze the correlation between FT3 and clinical measurements and biochemical indicators. Multivariate logistic regression analysis was used to determine independent predictors.
Patients with NAFLD had higher BMI, SBP, and DBP, longer duration of T2DM, and higher islet function index, blood glucose index, liver function index, renal function index, blood lipid index, and FT3. We also found that FT3 was affected by other five indicators, including ALT, CR, GGT, TC, and LDL-C only in the NAFLD group but not in the non-NAFLD group. FT3 was significantly associated with NAFLD in T2DM patients, and the prevalence of NAFLD increased gradually from the lowest FT3 tertile to the highest FT3 tertile ( for trend < 0.001).
FT3 is independently associated with NAFLD in hospitalized T2DM patients after rigorous adjustment for various metabolic parameters.
游离三碘甲状腺原氨酸（FT3）是甲状腺功能正常患者非酒精性脂肪性肝病（NAFLD）的独立危险因素。然而，FT3在2型糖尿病患者群体中对NAFLD是否具有独立影响尚不清楚。本研究的目的是确定FT3在2型糖尿病合并NAFLD中的潜在作用。
一项横断面研究。共纳入859例符合纳入标准的2型糖尿病患者。其中506例无NAFLD的2型糖尿病患者和353例有NAFLD的2型糖尿病患者。
对不同分布类型的连续变量采用独立样本t检验或Wilcoxon秩和检验，对分类变量采用卡方检验。采用Pearson相关分析和线性回归分析FT3与临床指标和生化指标之间的相关性。采用多因素logistic回归分析确定独立预测因素。
NAFLD患者的体重指数、收缩压和舒张压更高，2型糖尿病病程更长，胰岛功能指数、血糖指数、肝功能指数、肾功能指数、血脂指数和FT3更高。我们还发现，仅在NAFLD组中，FT3受其他五个指标影响，包括谷丙转氨酶、肌酐、谷氨酰转肽酶、总胆固醇和低密度脂蛋白胆固醇，而非NAFLD组中则无此现象。FT3与2型糖尿病患者的NAFLD显著相关，NAFLD的患病率从FT3三分位数最低组到最高组逐渐升高（趋势P<0.001）。
在对各种代谢参数进行严格调整后，住院2型糖尿病患者中FT3与NAFLD独立相关。
