瓣膜细胞外基质的蛋白质组学结构：FNDC1和MXRA5是主动脉瓣狭窄的新型生物标志物。

Proteomic Architecture of Valvular Extracellular Matrix: FNDC1 and MXRA5 Are New Biomarkers of Aortic Stenosis.

作者信息

Bouchareb Rihab, Guauque-Olarte Sandra, Snider Justin, Zaminski Devyn, Anyanwu Anelechi, Stelzer Paul, Lebeche Djamel

机构信息

Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

GIOD Group, Faculty of Dentistry, Universidad Cooperativa de Colombia, Pasto, Colombia.

出版信息

JACC Basic Transl Sci. 2021 Jan 13;6(1):25-39. doi: 10.1016/j.jacbts.2020.11.008. eCollection 2021 Jan.

This study analyzed the expression of extracellular matrix (ECM) proteins during aortic valve calcification with mass spectrometry, and further validated in an independent human cohort using RNAseq data. The study reveals that valve calcification is associated with significant disruption in ECM and metabolic pathways, and highlights a strong connection between metabolic markers and ECM remodeling. It also identifies FNDC1 and MXRA5 as novel ECM biomarkers in calcified valves, electing them as potential targets in the development and progression of aortic stenosis.