在人工膜系统中对肾小管二氧化碳扩散受限的现象学评估。
A phenomenologic evaluation of CO2-diffusion restriction in kidney tubules studied in an artificial membrane system.
作者信息
Sohtell M
出版信息
Acta Physiol Scand. 1979 Feb;105(2):129-36. doi: 10.1111/j.1748-1716.1979.tb06324.x.
The chemical course in a multi-membrane system with interacting H+ and HCO3 ions has been described phenomenologically as an analogy of the neutralisation reaction between secreted H+ and filtered HCO-3 ions in the proximal tubules of the kidney. It was shown that the produced CO2 gave the highest PCO2 in the asymmetrically placed reaction centre, which favours a build-up of a high intratubular PCO2. The CO2 transport was dependent on the rate-limiting permeation of the reacting ions, and the permeation could be increased by the influence of solutions of macromolecules such as carbonic anhydrase, albumin and dextran.
具有相互作用的H⁺和HCO₃⁻离子的多膜系统中的化学过程，已从现象学角度进行了描述，类比于肾脏近端小管中分泌的H⁺与滤过的HCO₃⁻离子之间的中和反应。结果表明，生成的CO₂在不对称放置的反应中心产生了最高的PCO₂，这有利于肾小管内高PCO₂的形成。CO₂的运输取决于反应离子的限速渗透，并且这种渗透可以通过诸如碳酸酐酶、白蛋白和右旋糖酐等大分子溶液的影响而增加。
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