State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Periodontics, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.
Department of Oral Implantology, School and Hospital of Stomatology, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Tongji University, Shanghai, China.
J Cell Physiol. 2021 Sep;236(9):6077-6089. doi: 10.1002/jcp.30310. Epub 2021 Feb 2.
The hedgehog (Hh) signaling pathway plays an essential role in both tissue development and homeostasis. Glioma-associated oncogene homolog 1 (Gli1) is one of the vital transcriptional factors as well as the direct target gene in the Hh signaling pathway. The cells expressing the Gli1 gene (Gli1 cells) have been identified as mesenchymal stem cells (MSCs) that are responsible for various tissue developments, homeostasis, and injury repair. This review outlines some recent discoveries on the crucial roles of Gli1 MSCs in the development and homeostasis of varieties of hard and soft tissues.
刺猬 (Hh) 信号通路在组织发育和稳态中起着至关重要的作用。Glioma-associated oncogene homolog 1 (Gli1) 是 Hh 信号通路中的关键转录因子之一，也是其直接靶基因。表达 Gli1 基因的细胞（Gli1 细胞）已被鉴定为间充质干细胞 (MSCs)，这些细胞负责各种组织的发育、稳态和损伤修复。本综述概述了最近关于 Gli1 MSCs 在各种硬组织和软组织发育和稳态中的关键作用的一些发现。
