Department of Neurology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China.
School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
Muscle Nerve. 2021 May;63(5):710-714. doi: 10.1002/mus.27190. Epub 2021 Feb 19.
Routine nerve conduction study (NCS) parameters are less sensitive in the early stage of carpal tunnel syndrome (CTS). Recently, some studies have shown that prolonged distal sensory nerve action potential (DSNAP) duration may be a more sensitive technique for the diagnosis of demyelinating peripheral neuropathies. We aimed to evaluate the sensitivity of median DSNAP duration in patients with CTS.
DSNAP duration and routine NCS data of the median nerve were retrospectively collected in 173 CTS patients, 73 controls, and 78 cervical radiculopathy patients.
Prolonged median DSNAP durations were found in 22 patients (22/35, 63%) and 36 patients (36/54, 67%) in the minimal and mild CTS groups respectively, which was more sensitive than routine NCS parameters. The percentage of patients demonstrating abnormalities in median NCS was significantly increased from 80% to 92% with the addition of DSNAP duration.
Our results demonstrate the electrodiagnostic value of median DSNAP duration for the diagnosis of CTS, especially in early cases.
常规神经传导研究（NCS）参数在腕管综合征（CTS）的早期阶段不太敏感。最近，一些研究表明，延长的远端感觉神经动作电位（DSNAP）持续时间可能是诊断脱髓鞘周围神经病变的更敏感技术。我们旨在评估 CTS 患者正中神经 DSNAP 持续时间的敏感性。
回顾性收集了 173 例 CTS 患者、73 例对照者和 78 例颈椎病患者的正中神经 DSNAP 持续时间和常规 NCS 数据。
在最小和轻度 CTS 组中，分别有 22 例（22/35，63%）和 36 例（36/54，67%）患者出现延长的正中 DSNAP 持续时间，其敏感性高于常规 NCS 参数。随着 DSNAP 持续时间的增加，正中 NCS 异常的患者比例从 80%显著增加到 92%。
我们的结果表明，正中 DSNAP 持续时间对 CTS 的诊断具有电诊断价值，尤其是在早期病例中。
