Chemistry in Pharmaceutical Sciences Department, Complutense University of Madrid, Plaza Ramón y Cajal s/n, 28040, Madrid, Spain.
Organic Chemistry Department, Autónoma University of Madrid, Francisco Tomás y Valiente 7, 28049, Madrid, Spain.
Chemistry. 2021 May 17;27(28):7593-7624. doi: 10.1002/chem.202005065. Epub 2021 Mar 24.
Glycodendrimers are an important class of synthetic macromolecules that can be used to mimic many structural and functional features of cell-surface glycoconjugates. Their carbohydrate moieties perform key important functions in bacterial and viral infections, often regulated by carbohydrate-protein interactions. Several studies have shown that the molecular structure, valency and spatial organisation of carbohydrate epitopes in glycoconjugates are key factors in the specificity and avidity of carbohydrate-protein interactions. Choosing the right glycodendrimers almost always helps to interfere with such interactions and blocks bacterial or viral adhesion and entry into host cells as an effective strategy to inhibit bacterial or viral infections. Herein, the state of the art in the design and synthesis of glycodendrimers employed for the development of anti-adhesion therapy against bacterial and viral infections is described.
糖缀合物是一类重要的合成高分子，可用于模拟细胞表面糖缀合物的许多结构和功能特征。它们的碳水化合物部分在细菌和病毒感染中发挥着重要作用，通常受碳水化合物-蛋白质相互作用的调节。有几项研究表明，糖缀合物中碳水化合物表位的分子结构、价数和空间组织是碳水化合物-蛋白质相互作用特异性和亲和力的关键因素。选择合适的糖缀合物通常有助于干扰这种相互作用，并阻止细菌或病毒黏附和进入宿主细胞，成为抑制细菌或病毒感染的有效策略。本文描述了用于开发抗细菌和病毒感染黏附治疗的糖缀合物的设计和合成的最新进展。
