Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China.
J Cosmet Dermatol. 2021 May;20(5):1396-1402. doi: 10.1111/jocd.13963. Epub 2021 Feb 5.
Hailey-Hailey disease is a rare disorder characterized by recurrent painful blistering, erosions, maceration in the intertriginous regions. Botulinum toxin has been used in the treatment of Hailey-Hailey disease.
This study aimed to examine all published articles on botulinum toxin in the treatment of Hailey-Hailey disease, and to evaluate its efficacy and safety.
PubMed, Embase, Cochrane Library, and Web of Science were used to identify eligible articles on August 8, 2020. The searching strategy was "(Hailey Hailey or Hailey-Hailey or pemphigus) and botulinum."
Sixteen articles including 38 patients described the use of botulinum toxin in treating Hailey-Hailey disease. Only one case had no response, while the other patients all had partial or complete remission. No side effects were reported. Nine articles including 10 patients mainly described other treatment options, and the patients were only treated with botulinum toxin previously. Their responses to botulinum toxin were limited: one was mild improvement, one was partial response, and the other eight failed.
Botulinum toxin is not almighty, but a promising alternative option. We recommend botulinum toxin as an adjuvant or supplemental treatment modality for severe and recalcitrant Hailey-Hailey disease. Larger studies are warranted to confirm its efficacy, safety, long-term effects, and cost performance.
Hailey-Hailey 病是一种罕见的疾病，其特征为反复发作的疼痛性水疱、糜烂，浸渍于皱褶部位。肉毒毒素已被用于治疗 Hailey-Hailey 病。
本研究旨在检查所有关于肉毒毒素治疗 Hailey-Hailey 病的已发表文献，并评估其疗效和安全性。
于 2020 年 8 月 8 日检索了 PubMed、Embase、Cochrane 图书馆和 Web of Science 中的相关文章，检索词为“(Hailey Hailey 或 Hailey-Hailey 或 pemphigus) 和 botulinum”。
共纳入 16 篇文章，包括 38 例患者，描述了肉毒毒素治疗 Hailey-Hailey 病的应用。仅有 1 例无反应，而其他患者均有部分或完全缓解。未报告不良反应。9 篇文章包括 10 例患者主要描述了其他治疗选择，这些患者以前仅接受过肉毒毒素治疗。他们对肉毒毒素的反应有限：1 例为轻度改善，1 例为部分缓解，8 例失败。
肉毒毒素并非万能，但却是一种很有前途的替代选择。我们建议将肉毒毒素作为严重和难治性 Hailey-Hailey 病的辅助或补充治疗方法。需要更大规模的研究来证实其疗效、安全性、长期效果和性价比。
