Alatortseva G I, Bakirova Z, Lukhverchik L N, Nurmatov A Z, Nurmatov Z S, Tashov K E, Nesterenko L N, Malinnikova Е Yu, Kasymov O T, Mikhailov M I, Zverev V V
I.I. Mechnikov Research Institute of Vaccines and Sera.
Osh Center for Disease Prevention and State Sanitary and Epidemiological Surveillance.
Vopr Virusol. 2020 Sep 17;65(4):218-227. doi: 10.36233/0507-4088-2020-65-4-218-227.
Hepatitis E (HE) is an important public health problem worldwide and is especially significant for pregnant women, among whom the associated mortality rate reaches 25%. The distribution of HE serological markers in this cohort in the endemic regions of Central Asia is poorly understood. The aim of the study was to assess the seroprevalence of HEV among pregnant women in the region of Kyrgyzstan where an increased incidence of HE is reported.
Blood serum of pregnant women, obtained from medical institutions in Bishkek, city of Osh and Osh region in the period from September 2016 to October 2019, and the control group of clinically healthy women were tested using the test systems "DS-IFA-ANTI-HEV-G" and "DS-IFA-ANTI-HEV-M" (NPO "Diagnostic Systems", Russia).
IgG antibodies to HEV were detected in 87 (5.9%) of 1472 examined pregnant women, IgM antibodies -in 64 (4.8%) of 1378, while 5 (0.34%) samples were simultaneously positive for IgG and IgM antibodies. The rates of detection of antibodies to HEV in women of three age categories from 17 to 36 years old in the studied and control groups were similar. The analysis of the seasonal dynamics of HEV seroprevalence in pregnant women in the period from February to September 2019 showed a tendency towards an increase in the values of the positivity coefficient of specific IgM antibodies by the beginning of the autumn. Antibodies to HEV were detected with highest frequency in women from Osh region.
A high risk of HEV infection for pregnant women in the surveyed region had been shown.
戊型肝炎（HE）是一个全球性的重要公共卫生问题，对孕妇尤为严重，孕妇中戊型肝炎相关死亡率达25%。人们对中亚流行地区这一队列中戊型肝炎血清学标志物的分布了解甚少。本研究的目的是评估吉尔吉斯斯坦地区孕妇中戊型肝炎病毒（HEV）的血清流行率，该地区报告戊型肝炎发病率有所上升。
2016年9月至2019年10月期间，从比什凯克、奥什市和奥什地区的医疗机构采集孕妇血清，并使用“DS-IFA-ANTI-HEV-G”和“DS-IFA-ANTI-HEV-M”检测系统（俄罗斯“诊断系统”非营利组织）对临床健康女性对照组进行检测。
在1472名接受检查的孕妇中，87名（5.9%）检测出抗HEV IgG抗体，1378名中有64名（4.8%）检测出抗HEV IgM抗体，同时有5份（0.34%）样本IgG和IgM抗体均呈阳性。研究组和对照组中17至36岁三个年龄组女性的HEV抗体检测率相似。对2019年2月至9月期间孕妇中HEV血清流行率的季节性动态分析显示，到秋季开始时，特异性IgM抗体阳性系数值有增加趋势。奥什地区女性中检测到HEV抗体的频率最高。
已表明被调查地区孕妇感染HEV的风险很高。
