Department of Chemistry, Istanbul Technical University, Maslak 34469, Istanbul, Turkey and Department of Chemistry, Middle East Technical University, Çankaya 06800, Ankara, Turkey.
Department of Chemistry, Istanbul Technical University, Maslak 34469, Istanbul, Turkey.
Dalton Trans. 2021 Mar 2;50(8):2736-2745. doi: 10.1039/d0dt04351f.
This study presents the synthesis of a series of new tetra-substituted phthalocyanines bearing 3,5-bis(trifluoromethyl)phenoxy groups at non-peripheral positions. The resulting macromolecules were characterized by performing different spectroscopic methods including 1H NMR, UV-Vis, FT-IR, and mass spectroscopy. In this study, the synergistic effect of phthalocyanines used as colorants in ink formulas with other chemicals available was probed for the first time. The synergistic effect of methyl laurate on the biological and antioxidant activities of the compounds (2-5) was investigated. Moreover, the therapeutic properties of the complexes (3, 6, and 7) were investigated using photochemical methods. Upon comparison, complex 7 (ΦΔ = 0.42) was found to be more effective than complex 6 (ΦΔ = 0.40) and complex 3 (ΦΔ = 0.27) in terms of producing singlet oxygen. The results confirmed that the heavy atom effect improves the therapeutic effects.
本研究提出了一系列新的四取代酞菁的合成，其在非外围位置带有 3,5-双（三氟甲基）苯氧基基团。通过执行不同的光谱方法，包括 1H NMR、UV-Vis、FT-IR 和质谱，对得到的大分子进行了表征。在这项研究中，首次探讨了酞菁作为油墨配方中着色剂与其他可用化学物质的协同效应。研究了月桂酸甲酯对化合物（2-5）的生物和抗氧化活性的协同作用。此外，还通过光化学方法研究了配合物（3、6 和 7）的治疗特性。通过比较，发现配合物 7（ΦΔ = 0.42）在产生单线态氧方面比配合物 6（ΦΔ = 0.40）和配合物 3（ΦΔ = 0.27）更有效。结果证实，重原子效应提高了治疗效果。
