Acta Chim Slov. 2020 Dec;67(4):1024-1034.
A number of important fused heterocyclic systems have been prepared by the reaction of 4-((3,5-diamino-1H-pyrazol-4-yl)-diazenyl)-N-(thiazol-2-yl)-benzenesulfonamide with some bifunctional nucleophiles such as ethyl acetoacetate, acetylacetone or arylidenemalonononitrile derivatives to obtain pyrazolo[1,5-a]pyrimidine derivatives. The structures of the newly synthesized compounds were determined based on their IR, 1H and 13C NMR and mass spectroscopic data. Most of the compounds produced showed good antibacterial and antifungal activity.
通过 4-((3,5-二氨基-1H-吡唑-4-基)-重氮基)-N-(噻唑-2-基)-苯磺酰胺与一些双官能亲核试剂（如乙酰乙酸乙酯、乙酰丙酮或芳基亚甲基丙二腈衍生物）的反应，合成了一些重要的稠合杂环体系，得到了吡唑并[1,5-a]嘧啶衍生物。根据新合成化合物的红外光谱、1H 和 13C NMR 以及质谱数据确定了它们的结构。大多数生成的化合物表现出良好的抗菌和抗真菌活性。
