新型二酰胺和三酰胺的合成作为水相不对称Aldol 反应的潜在有机催化剂。
Synthesis of New Di- and Triamides as Potential Organocatalysts for Asymmetric Aldol Reaction in Water.
出版信息
Acta Chim Slov. 2020 Dec;67(4):1014-1023.
New di- or triamide organocatalysts derived from (L)-proline were synthesized and successfully used in the direct asymmetric aldol reaction of aliphatic ketones and aromatic aldehydes in water at 0oC in the presence of benzoic acid as co-catalyst. (S)-methyl-2-((S)-3-hydroxy-2-((S)-3-pyrrolidine-2-carboxamido)propanamido)-3-phenylpropanoate (7c) as organocatalyst showed best results under these reaction conditions, and good diastereoselectivities (up to 99%), enantioselectivities (up to 98%) and yields (up to 91%) were observed.
合成了新的二或三酰胺手性有机催化剂，来源于（L）-脯氨酸，在苯甲酸作为共催化剂的存在下，成功地用于脂肪酮和芳香醛在水中的直接不对称羟醛缩合反应。在这些反应条件下，（S）-甲基-2-（（S）-3-羟基-2-（（S）-3-吡咯烷-2-羧酰胺基）丙酰胺基）-3-苯基丙酸酯（7c）作为有机催化剂表现出最佳的结果，观察到良好的非对映选择性（高达 99%），对映选择性（高达 98%）和产率（高达 91%）。
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