Acta Chim Slov. 2020 Dec;67(4):1155-1162.
A new copper(II) complex [Cu(L1)(NCS)(CH3OH)] (1) and a new zinc(II) complex [ZnCl2(HL2)]·CH3OH (2), derived from 4-bromo-N'-(pyridin-2-ylmethylene)benzohydrazide (HL1) and 4-methoxy-N'-(pyridin-2-ylmethylene)benzohydrazide (HL2), were prepared and characterized by elemental analysis, IR and UV-Vis spectroscopy and single crystal X-ray diffraction. The hydrazone HL1 coordinates to the Cu atom in enolate form, while the hydrazone HL2 coordinates to the Zn atom in carbonyl form. Single crystal structural analyses indicate that the hydrazones coordinate to the metal atoms through the pyridine N, imino N, and enolate/carbonyl O atoms. The Cu atom in complex 1 is in square pyramidal coordination, and the Zn atom in complex 2 is in trigonal-bipyramidal coordination. The inhibitory effects of the complexes on Jack bean urease were studied, which show that the copper complex has strong activity on urease.
一种新的铜（II）配合物[Cu(L1)(NCS)(CH3OH)]（1）和一种新的锌（II）配合物[ZnCl2(HL2)]·CH3OH（2），由 4-溴-N'-(吡啶-2-亚甲基)苯甲酰肼（HL1）和 4-甲氧基-N'-(吡啶-2-亚甲基)苯甲酰肼（HL2）制备并通过元素分析、红外和紫外可见光谱以及单晶 X 射线衍射进行了表征。腙 HL1 以烯醇式与 Cu 原子配位，而腙 HL2 以羰基形式与 Zn 原子配位。单晶结构分析表明，腙通过吡啶 N、亚氨基 N 和烯醇/羰基 O 原子与金属原子配位。配合物 1 中的 Cu 原子处于四方锥配位，配合物 2 中的 Zn 原子处于三角双锥配位。研究了配合物对刀豆脲酶的抑制作用，结果表明铜配合物对脲酶具有很强的活性。
