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右美托咪定对大鼠胃缺血再灌注损伤的作用。生化和组织病理学评价。

The effect of dexmedetomidine on gastric ischemia reperfusion injury in rats. Biochemical and histopathological evaluation.

机构信息

Associate Professor. Erzincan Binali Yıldırım University - Faculty of Medicine - Department of Anesthesiology and Reanimation - Erzincan, Turkey.

PhD. Malatya Research and Training Hospital - Department of Anesthesiology and Reanimation - Malatya, Turkey.

出版信息

Acta Cir Bras. 2021 Feb 1;36(1):e360104. doi: 10.1590/ACB360104. eCollection 2021.

DOI:10.1590/ACB360104
PMID:33533828
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7853698/
Abstract

PURPOSE

To evaluate the protective effect of dexmedetomidine on gastric injury induced by ischemia reperfusion (I/R) in rats.

METHODS

A total of 18 male albino Wistar rats were divided groups as: gastric ischemia reperfusion (GIR), gastric ischemia reperfusion and 50 μg/kg dexmedetomidine (DGIR) and sham operation (HG) group. After the third hour of reperfusion, the biochemical and histopathological examinations were performed on the removed stomach tissue.

RESULTS

Malondialdehyde (MDA) and myeloperoxidase (MPO) levels were found to be significantly higher in GIR compared to HG (p < 0.05). A statistically significant decrease was observed at the DGIR compared to the GIR for oxidants levels. Total glutathione (tGSH) and superoxide dismutase (SOD) levels were statistically significantly decreased at the GIR, and antioxidants levels were found to be significantly higher in the DGIR (p < 0.05) There was no significant difference between HG and DGIR in terms of SOD (p = 0.097). The DGIRs' epitheliums, glands and vascular structures were close to normal histological formation.

CONCLUSIONS

Dexmedetomidine is found to prevent oxidative damage on the stomach by increasing the antioxidant effect. These results indicate that dexmedetomidine may be useful in the treatment of ischemia-reperfusion-related gastric damage.

摘要

目的

评估右美托咪定对大鼠缺血再灌注（I/R）性胃损伤的保护作用。

方法

将 18 只雄性白化 Wistar 大鼠随机分为胃缺血再灌注（GIR）组、胃缺血再灌注和 50μg/kg 右美托咪定（DGIR）组及假手术（HG）组。再灌注 3 小时后，对切除的胃组织进行生化和组织病理学检查。

结果

与 HG 组相比，GIR 组丙二醛（MDA）和髓过氧化物酶（MPO）水平显著升高（p<0.05）。与 GIR 组相比，DGIR 组的氧化剂水平显著降低。GIR 组总谷胱甘肽（tGSH）和超氧化物歧化酶（SOD）水平显著降低，DGIR 组抗氧化剂水平显著升高（p<0.05）。HG 组和 DGIR 组的 SOD 水平无统计学差异（p=0.097）。DGIR 组的上皮、腺体和血管结构接近正常的组织学形态。

结论

右美托咪定通过增加抗氧化作用来防止胃的氧化损伤。这些结果表明，右美托咪定可能对缺血再灌注相关胃损伤的治疗有用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3662/7853698/f2effea99bc5/1678-2674-acb-36-1-e360104-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3662/7853698/90dcf91d8060/1678-2674-acb-36-1-e360104-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3662/7853698/ea11aead7d3a/1678-2674-acb-36-1-e360104-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3662/7853698/0474311f80c8/1678-2674-acb-36-1-e360104-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3662/7853698/f44a12f51ba4/1678-2674-acb-36-1-e360104-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3662/7853698/88dd916fecc7/1678-2674-acb-36-1-e360104-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3662/7853698/f2effea99bc5/1678-2674-acb-36-1-e360104-gf06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3662/7853698/90dcf91d8060/1678-2674-acb-36-1-e360104-gf01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3662/7853698/ea11aead7d3a/1678-2674-acb-36-1-e360104-gf02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3662/7853698/0474311f80c8/1678-2674-acb-36-1-e360104-gf03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3662/7853698/f44a12f51ba4/1678-2674-acb-36-1-e360104-gf04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3662/7853698/88dd916fecc7/1678-2674-acb-36-1-e360104-gf05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3662/7853698/f2effea99bc5/1678-2674-acb-36-1-e360104-gf06.jpg

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