Rillema J A, Whale M A
Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan 48201.
Proc Soc Exp Biol Med. 1988 Apr;187(4):432-4. doi: 10.3181/00379727-187-42684.
One of the most rapid actions of prolactin in mouse mammary gland explants is the stimulation of ornithine decarboxylase (ODC) activity. Several protein kinase C activators including mezerein, dicaprin, diolein, and 1-oleoyl-2-acetyl-rac-glycerol were found to stimulate ODC activity as does prolactin. Both mezerein and the diglycerides produced nonadditive responses when tested with maximum stimulatory concentrations of prolactin. The results of these studies therefore provide further evidence that the prolactin stimulation of ODC activation in the mammary gland may involve an activation of protein kinase C.
催乳素对小鼠乳腺外植体最快速的作用之一是刺激鸟氨酸脱羧酶（ODC）的活性。已发现几种蛋白激酶C激活剂，包括狼毒素、癸二酰精胺、二油精和1-油酰基-2-乙酰基-rac-甘油，与催乳素一样能刺激ODC活性。当用最大刺激浓度的催乳素进行测试时，狼毒素和甘油二酯均产生非加性反应。因此，这些研究结果进一步证明，催乳素对乳腺中ODC激活的刺激可能涉及蛋白激酶C的激活。
