脑膜瘤瘤周水肿体积与肿瘤各向异性分数相关，但与表观扩散系数或脑血容量无关。
Peritumoral brain edema volume in meningioma correlates with tumor fractional anisotropy but not apparent diffusion coefficient or cerebral blood volume.
机构信息
Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou and Chang Gung University College of Medicine, No.5, Fuxing St., Guishan Dist., Taoyuan, 333, Taiwan.
Department of Radiology, University of North Carolina School of Medicine, Chapel Hill, NC, USA.
出版信息
Neuroradiology. 2021 Aug;63(8):1263-1270. doi: 10.1007/s00234-021-02646-6. Epub 2021 Feb 3.
PURPOSE
Pathogenesis of peritumoral brain edema (PTBE) in meningiomas remains unclear. Associations between PTBE volume and diffusion or perfusion properties of meningioma have not been studied. We aimed to investigate if diffusion and perfusion properties of meningioma correlate with its PTBE volume.
METHODS
Seventy consecutive patients (mean age, 58.9 ± 13.7 years; 37 women) with meningiomas who had preoperative DTI and DSC-PWI were retrospectively analyzed. PTBE volume, tumor volume, and mean T2 signal, ADC, FA, and CBV of the tumor were measured. Between meningiomas with and without PTBE, patient age and sex, as well as T2 signal intensity, volume, ADC, FA, and CBV of tumors, were compared. In meningiomas with PTBE, correlations of PTBE volume with patient age and sex, as well as T2 signal intensity, volume, ADC, FA, and CBV of tumors, were analyzed. Multivariable linear regression analysis was performed to identify factors associated with PTBE volume.
RESULTS
On univariable analysis, meningiomas without PTBE were more frequently found in women (P = 0.033) and demonstrated lower ADC (P = 0.020), higher FA (P < 0.001), and lower CBV (P < 0.001). PTBE volume of meningiomas correlated with tumor ADC (r = 0.444; P = 0.001), tumor FA (r = - 0.655; P < 0.001), and tumor CBV (r = 0.402; P = 0.003). On multivariable analysis, tumor FA was the only factor associated with PTBE volume (P < 0.001).
CONCLUSION
PTBE volume in meningioma correlates with tumor FA. DTI may help to understand the mechanism of PTBE in meningiomas.
目的
脑膜瘤瘤周水肿（PTBE）的发病机制仍不清楚。脑膜瘤的 PTBE 体积与弥散或灌注特性之间的关系尚未研究。我们旨在研究脑膜瘤的弥散和灌注特性与其 PTBE 体积是否相关。
方法
回顾性分析了 70 例连续的脑膜瘤患者（平均年龄 58.9±13.7 岁，37 名女性）的术前 DTI 和 DSC-PWI 数据。测量了 PTBE 体积、肿瘤体积以及肿瘤的平均 T2 信号强度、ADC、FA 和 CBV。比较了有和无 PTBE 的脑膜瘤之间的患者年龄和性别，以及肿瘤的 T2 信号强度、体积、ADC、FA 和 CBV。在有 PTBE 的脑膜瘤中，分析了 PTBE 体积与患者年龄和性别，以及肿瘤的 T2 信号强度、体积、ADC、FA 和 CBV 之间的相关性。采用多元线性回归分析来确定与 PTBE 体积相关的因素。
结果
在单变量分析中，无 PTBE 的脑膜瘤更常见于女性（P=0.033），并且 ADC 较低（P=0.020），FA 较高（P<0.001），CBV 较低（P<0.001）。脑膜瘤的 PTBE 体积与肿瘤 ADC（r=0.444；P=0.001）、肿瘤 FA（r=-0.655；P<0.001）和肿瘤 CBV（r=0.402；P=0.003）相关。在多变量分析中，肿瘤 FA 是唯一与 PTBE 体积相关的因素（P<0.001）。
结论
脑膜瘤的 PTBE 体积与肿瘤 FA 相关。DTI 可能有助于了解脑膜瘤 PTBE 的发生机制。
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