阻断大脑M2毒蕈碱受体可降低自发性高血压大鼠的血压。

Blockade of brain M2 muscarinic receptors lowers blood pressure in spontaneously hypertensive rats.

作者信息

Brezenoff H E, Vargas H, Xiao Y F

机构信息

Department of Pharmacology, University of Medicine and Dentistry of New Jersey, Newark.

出版信息

Pharmacology. 1988;36(2):101-5. doi: 10.1159/000138365.

DOI:10.1159/000138365

PMID:3353437

Abstract

Injections of the M2 muscarinic receptor antagonist 4-diphenylacetoxy-N-methylpiperidine methiodide (4-DAMP; 1.5-40 micrograms) into the cerebral ventricles of urethane-anesthetized rats caused a dose-related inhibition of the pressor response to intravenously injected physostigmine. A similar reduction was obtained with 1/80th the dose of methylatropine, but not with the selective M1 antagonist pirenzepine. Intraventricular injection of 4-DAMP (6.25-25 micrograms) caused a dose-related reduction in blood pressure in unanesthetized spontaneously hypertensive rats (SHR), but not in normotensive controls. Systolic pressure fell 42 +/- 6 mm Hg at the 25-micrograms dose. Pirenzepine did not lower blood pressure in SHR and inhibited the antihypertensive effect of 4-DAMP.

摘要

向用乌拉坦麻醉的大鼠脑室内注射M2毒蕈碱受体拮抗剂4-二苯乙酰氧基-N-甲基哌啶甲基碘化物（4-DAMP；1.5 - 40微克），可引起对静脉注射毒扁豆碱的升压反应呈剂量相关的抑制。使用1/80剂量的甲基阿托品可获得类似的降低效果，但选择性M1拮抗剂哌仑西平则无此作用。向未麻醉的自发性高血压大鼠（SHR）脑室内注射4-DAMP（6.25 - 25微克）可导致血压呈剂量相关的降低，但对正常血压对照大鼠则无此作用。在25微克剂量时，收缩压下降42±6毫米汞柱。哌仑西平不会降低SHR的血压，且会抑制4-DAMP的降压作用。