泰国性别健康诊所中转性别女性的阴道和肛门高危型人乳头瘤病毒 DNA 。

Neovaginal and Anal High-Risk Human Papillomavirus DNA Among Thai Transgender Women in Gender Health Clinics.

机构信息

From the Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University and King Chulalongkorn Memorial Hospital.

Department of Medical Education and Clinical Research center, Bumrungrad Hospital, Bangkok, Thailand.

出版信息

Sex Transm Dis. 2021 Aug 1;48(8):547-549. doi: 10.1097/OLQ.0000000000001388.

DOI:10.1097/OLQ.0000000000001388

PMID:33534409

Abstract

BACKGROUND

Although human papillomavirus (HPV)-related lesions in the neovagina of transgender women have been well documented, information on high-risk HPV (hrHPV) in the neovagina has been very limited. The objective of this study was to determine hrHPV DNA detection rate in the neovagina of transgender women.

METHODS

Neovaginal and anal swab were collected in liquid-based cytology fluid from transgender women visiting Gender Health Clinic and Tangerine Community Health Clinic in Bangkok, Thailand. Samples were processed for hrHPV DNA (reported as subtypes 16 and 18 or the pooled result of subtypes 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 66) by automated real-time polymerase chain reaction and for neovaginal cytology according to the Bethesda system. Demographic data and sexual history were obtained, and physical examination was conducted. HIV status was obtained from existing medical records.

RESULTS

Samples were collected from 57 transgender women (mean age, 30.4 years [interquartile range, 8 years]). From 35 of 57 valid neovaginal samples, 8 (20%) tested positive for hrHPV DNA. From 30 of 57 valid anal samples, 6 (19.4%) tested positive for hrHPV DNA. HIV status was known for 52 transgender women, 1 of which were HIV infected; neovaginal hrHPV was invalid in that patient.

CONCLUSIONS

One of 5 transgender women visiting sexual health clinics in Bangkok was found to have hrHPV DNA in neovaginal and anal compartments. Studies are needed to look at incidence and persistence of hrHPV infection to inform anogenital precancerous and cancerous screening programs for transgender women.

摘要

背景

尽管已有大量文献报道了跨性别女性新阴道中的人乳头瘤病毒（HPV）相关病变，但有关新阴道中高危型 HPV（hrHPV）的信息却非常有限。本研究旨在确定曼谷性别健康诊所和 Tangerine 社区健康诊所就诊的跨性别女性新阴道中 hrHPV DNA 的检出率。

方法

从泰国曼谷的性别健康诊所和 Tangerine 社区健康诊所就诊的跨性别女性收集新阴道和肛门拭子，置于液基细胞学采集液中。采用自动化实时聚合酶链反应检测 hrHPV DNA（报告为亚型 16 和 18 或亚型 31、33、35、39、45、51、52、56、58、59 和 66 的混合结果），并按照巴氏系统对新阴道细胞学进行检测。收集人口统计学数据和性行为史，并进行体格检查。从现有病历中获取 HIV 感染状况。

结果

共采集了 57 名跨性别女性（平均年龄 30.4 岁[四分位间距，8 年]）的样本。35 份有效新阴道样本中有 8 份（20%）检测出 hrHPV DNA 阳性，30 份有效肛门样本中有 6 份（19.4%）检测出 hrHPV DNA 阳性。52 名跨性别女性的 HIV 感染状况已知，其中 1 人 HIV 感染，该患者的新阴道 hrHPV 检测结果无效。