Department of Human Biology, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, Maastricht, the Netherlands.
Department of Nutrition, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia.
Diabetes Care. 2020 Jul;43(7):1659-1669. doi: 10.2337/dc19-2265.
Vitamin D has been suggested to affect peripheral insulin sensitivity. Evidence regarding the effect of vitamin D supplementation on insulin sensitivity is still conflicting.
This meta-analysis aimed to assess the effect of vitamin D supplementation on insulin sensitivity in humans with or at risk for insulin resistance.
PubMed, Web of Science, Embase, CINAHL, and Cochrane Library were systematically searched for randomized controlled trials (RCTs) from 1980 until 31 December 2018 reporting treatment effects of vitamin D supplementation on insulin sensitivity.
The main outcome of interest was the change in insulin sensitivity, derived from the gold standard hyperinsulinemic-euglycemic clamp or the Matsuda index derived from the oral glucose tolerance test and insulin sensitivity index from intravenous glucose tolerance test. We extracted data on the standardized mean difference between the vitamin D treatment and placebo groups in change from baseline insulin sensitivity.
Eighteen RCTs were included in this meta-analysis comparing vitamin D supplementation ( = 612) with placebo ( = 608). Vitamin D supplementation had no effect on insulin sensitivity (standardized mean difference -0.01, 95% CI -0.12, 0.10; = 0.87, = 0%). Visual inspection of funnel plot symmetry did not suggest potential publication bias.
The number of individuals who participated in the included studies was relatively small, possibly due to the invasive character of the measurement (e.g., clamp).
This meta-analysis provides no evidence that vitamin D supplementation has a beneficial effect on peripheral insulin sensitivity in people with or at risk for insulin resistance.
维生素 D 被认为会影响外周胰岛素敏感性。关于维生素 D 补充对胰岛素敏感性的影响，目前仍存在争议。
本荟萃分析旨在评估维生素 D 补充对存在或有胰岛素抵抗风险的人群胰岛素敏感性的影响。
系统检索了 PubMed、Web of Science、Embase、CINAHL 和 Cochrane Library 中的随机对照试验（RCT），以获取截至 2018 年 12 月 31 日有关维生素 D 补充对胰岛素敏感性影响的报告。
主要观察指标是胰岛素敏感性的变化，来源于金标准高胰岛素-正葡萄糖钳夹或口服葡萄糖耐量试验衍生的 Matsuda 指数和静脉葡萄糖耐量试验衍生的胰岛素敏感性指数。我们提取了维生素 D 治疗组与安慰剂组在基线胰岛素敏感性变化方面的标准化均数差值数据。
本荟萃分析纳入了 18 项 RCT，比较了维生素 D 补充（n=612）与安慰剂（n=608）的效果。维生素 D 补充对胰岛素敏感性没有影响（标准化均数差值-0.01，95%置信区间-0.12，0.10；=0.87，=0.00）。漏斗图对称性的视觉检查并未提示存在潜在的发表偏倚。
参与研究的个体数量相对较少，这可能是由于测量的侵袭性特征（例如钳夹）所致。
本荟萃分析并未提供证据表明维生素 D 补充对存在或有胰岛素抵抗风险的人群的外周胰岛素敏感性有有益影响。
