Nosek Hanna, Jankowska Dorota, Brzozowska Karolina, Kazberuk Katarzyna, Wasilewska Anna, Taranta-Janusz Katarzyna
Department of Pediatrics, Gastroenterology and Nutrition, University of Warmia and Mazury, 10-719 Olsztyn, Poland.
Department of Statistics and Medical Informatics, Medical University of Bialystok, 15-295 Białystok, Poland.
J Clin Med. 2021 Feb 1;10(3):497. doi: 10.3390/jcm10030497.
This study was performed to explore serum tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its dependent cytokines urinary excretion: monocyte chemoattractant protein- (MCP-1) and regulated on activation, normal T cell expressed and secreted chemokine (RANTES) with their relation to the kidney function parameters in children with solitary functioning kidney (SFK). The study included 80 children and adolescents (median age 9.75 year) with congenital and acquired (after surgical removal) SFK. Serum TWEAK and urinary MCP-1 and RANTES levels were significantly higher in SFK patients ( < 0.05). The serum TWEAK was positively related to serum creatinine ( = 0.356; < 0.001). Moreover, in SFK the receiver operating characteristic analyses revealed good diagnostic profile for serum TWEAK with AUC (Area Under The Curve)-0.853, uRANTES-0.757, and for RANTES/cr.: AUC-0.816. Analysis carried out to identify children with impaired renal function (albuminuria and/or decreased estimated glomerular filtration rate < 90 mL/min/1.73 m and/or hypertension) showed good profile for TWEAK (AUC-0.79) and quite good profile for uRANTES and RANTES/cr. (AUC 0.66 and 0.631, respectively). This is the first study investigating serum TWEAK and urinary excretion of MCP-1 and RANTES together in children with SFK. Obtained results indicate that TWEAK and RANTES may serve as potential markers of renal impairment.
本研究旨在探讨血清肿瘤坏死因子样凋亡弱诱导剂（TWEAK）及其相关细胞因子的尿排泄情况：单核细胞趋化蛋白-1（MCP-1）和活化调节正常T细胞表达和分泌的趋化因子（RANTES），以及它们与孤立功能性肾（SFK）患儿肾功能参数的关系。该研究纳入了80名患有先天性和后天性（手术后）SFK的儿童和青少年（中位年龄9.75岁）。SFK患者的血清TWEAK、尿MCP-1和RANTES水平显著更高（<0.05）。血清TWEAK与血清肌酐呈正相关（=0.356；<0.001）。此外，在SFK患者中，受试者工作特征分析显示血清TWEAK具有良好的诊断特征，曲线下面积（AUC）为0.853，尿RANTES为0.757，RANTES/肌酐为0.816。为识别肾功能受损儿童（蛋白尿和/或估计肾小球滤过率降低<90 mL/min/1.73 m²和/或高血压）所进行的分析表明，TWEAK具有良好的特征（AUC为0.79），尿RANTES和RANTES/肌酐具有较好的特征（AUC分别为0.66和0.631）。这是第一项同时研究SFK患儿血清TWEAK以及MCP-1和RANTES尿排泄情况的研究。所得结果表明，TWEAK和RANTES可能是肾功能损害的潜在标志物。
