Dulaney M, Hume A S
Dept. of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson 39216.
Res Commun Chem Pathol Pharmacol. 1988 Jan;59(1):133-6.
The efficacy of pyruvic acid in protecting mice against the lethal effects of sodium sulfide was examined. Pyruvic acid (1 g/kg, i.p.) reduced the mortality of sodium sulfide (100 mg/kg, i.p.) from 100% to 5% when administered 15 min prior to the sulfide. The protective effect of pyruvic acid decreased over time but was still present at 20 min and 30 min, with 40% and 50% mortality, respectively. The lethality of sulfide in larger mice was less than that in smaller mice when the doses were normalized for body weight, but the protection factor of the pyruvic acid, approximately 2.0, was the same for both sizes.
研究了丙酮酸对小鼠免受硫化钠致死效应的保护作用。在给予硫化钠前15分钟腹腔注射丙酮酸（1克/千克），可使腹腔注射硫化钠（100毫克/千克）的小鼠死亡率从100%降至5%。丙酮酸的保护作用随时间减弱，但在20分钟和30分钟时仍存在，死亡率分别为40%和50%。当按体重标准化剂量时，较大小鼠中硫化物的致死率低于较小小鼠，但丙酮酸的保护系数约为2.0，对两种大小的小鼠相同。
