Universita degli Studi di Catania, Dipartimento di Scienze Biomediche e Biotecnologiche BIOMETEC, Sez. Microbiologia, Torre Biologica, via S. Sofia 89, 95123, Italy.
Mini Rev Med Chem. 2021;21(13):1596-1611. doi: 10.2174/1389557521666210203154541.
Today, a new β-coronavirus called SARS-CoV-2 has emerged and it is causing a global pandemic. Inter-human transmission studies have indicated a significant role of aerosols in the transmission of many respiratory viruses. Hence, it is very important to decrease the spread of the virus through disinfectant agents. This review aimed to provide an overview related to possible alternative inhibitory molecules against this virus.
The literature search was performed in the MEDLINE electronic database using the public access known as NCBI-PUBMED. Keywords "coronavirus" and "SARS-CoV-2" and "COVID19" were used. No specific time range was used.
We provide a review related to structure, anti-coronavirus activity and molecular mechanism of natural substances and semisynthetic derivatives such as glycopeptides, lipopeptides, probiotics, surfactants, terpenes and resveratrol. We also include the latest in vitro experiments with anti-SARSCoV- 2 activity. We also provide the theoretical basis for discussing the prospects of such natural molecules as possible alternative anti-Coronavirus products, so as to develop a complete screening for future applications.
In summary, this review suggest to investigate deeper several molecules most of which belong to natural substances to fight COVID19 disease.
如今，一种名为 SARS-CoV-2 的新型β冠状病毒出现，引发了全球性大流行。人际传播研究表明，气溶胶在许多呼吸道病毒的传播中起着重要作用。因此，通过消毒剂来降低病毒的传播非常重要。本综述旨在提供有关针对该病毒的可能替代抑制分子的概述。
使用公共访问的 NCBI-PUBMED 在 MEDLINE 电子数据库中进行文献检索。使用的关键词是“冠状病毒”和“SARS-CoV-2”和“COVID19”。未使用特定的时间范围。
我们提供了与天然物质和半合成衍生物（如糖肽、脂肽、益生菌、表面活性剂、萜类化合物和白藜芦醇）的结构、抗冠状病毒活性和分子机制相关的综述。我们还包括了具有抗 SARS-CoV-2 活性的最新体外实验。我们还为讨论这些天然分子作为可能的替代抗冠状病毒产品的前景提供了理论依据，以便为未来的应用进行全面筛选。
总之，本综述建议更深入地研究其中大部分属于天然物质的几种分子，以对抗 COVID19 疾病。
