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MicroRNA-210 靶向 FBXO31 抑制食管鳞癌细胞的肿瘤进展并调节 Wnt/β-catenin 信号通路和 EMT。

MicroRNA-210 targets FBXO31 to inhibit tumor progression and regulates the Wnt/β-catenin signaling pathway and EMT in esophageal squamous cell carcinoma.

机构信息

Department of Gastroenterology, Rizhao Hospital of TCM, Rizhao, China.

Department of General Surgery, People's Hospital of Rizhao, Rizhao, China.

出版信息

Thorac Cancer. 2021 Mar;12(6):932-940. doi: 10.1111/1759-7714.13860. Epub 2021 Feb 3.

DOI:10.1111/1759-7714.13860
PMID:33538099
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7952796/
Abstract

Evidence from previous studies showed that the dysregulation of microRNA (miR) is frequently associated with tumor progression. The aberrant miR-210 expression has been identified in a variety of tumors. However, its biological roles in esophageal squamous cell carcinoma (ESCC) still need further elucidation. Thus, in the current study we explore the roles of miR-210 in ESCC progression. The findings of our study reveal that miR-210 is down-regulated in ESCC, which indicates poor prognosis and aggressive tumor progression. Moreover, miR-210 restoration was found to enhance ESCC viability, invasion, and migration abilities. F-Box only protein 31 (FBXO31) was confirmed to be one of the targets of miR-210 in ESCC cells. Results also revealed that miR-210 played crucial roles in regulating ESCC cell epithelial-mesenchymal transition (EMT) and Wnt/β-catenin signaling. In conclusion, data show that miR-210 serves as an anti-ESCC miR via down-regulation of FBXO31 and regulation of EMT and Wnt signaling, suggesting that the miR-210/FBXO31 axis may function as promising therapeutic targets and effective prognostic markers for ESCC patients.

摘要

先前的研究证据表明，microRNA（miR）的失调经常与肿瘤进展有关。在各种肿瘤中已经鉴定出异常的 miR-210 表达。然而，其在食管鳞状细胞癌（ESCC）中的生物学作用仍需要进一步阐明。因此，在本研究中，我们探讨了 miR-210 在 ESCC 进展中的作用。我们的研究结果表明，miR-210 在 ESCC 中下调，这表明预后不良和侵袭性肿瘤进展。此外，发现 miR-210 恢复可增强 ESCC 的活力、侵袭和迁移能力。证实 F-Box 仅蛋白 31（FBXO31）是 ESCC 细胞中 miR-210 的靶标之一。结果还表明，miR-210 在调节 ESCC 细胞上皮-间充质转化（EMT）和 Wnt/β-catenin 信号通路中起着关键作用。总之，数据表明，miR-210 通过下调 FBXO31 以及调节 EMT 和 Wnt 信号来发挥抗 ESCC miR 的作用，表明 miR-210/FBXO31 轴可能是 ESCC 患者有前途的治疗靶点和有效的预后标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc7/7952796/7e356ee70968/TCA-12-932-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc7/7952796/00b178696abe/TCA-12-932-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc7/7952796/88def32ed881/TCA-12-932-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc7/7952796/8cea8326247c/TCA-12-932-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc7/7952796/28838effafb6/TCA-12-932-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc7/7952796/4d4dc0f30841/TCA-12-932-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc7/7952796/07da32b5864d/TCA-12-932-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc7/7952796/7e356ee70968/TCA-12-932-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc7/7952796/00b178696abe/TCA-12-932-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc7/7952796/88def32ed881/TCA-12-932-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc7/7952796/8cea8326247c/TCA-12-932-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc7/7952796/28838effafb6/TCA-12-932-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc7/7952796/4d4dc0f30841/TCA-12-932-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc7/7952796/07da32b5864d/TCA-12-932-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dc7/7952796/7e356ee70968/TCA-12-932-g002.jpg

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[1]
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[6]
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本文引用的文献

[1]
MiR-25-3p targets PTEN to regulate the migration, invasion, and apoptosis of esophageal cancer cells via the PI3K/AKT pathway.

Biosci Rep. 2020-10-30

[2]
MicroRNA (MiR)-301a-3p regulates the proliferation of esophageal squamous cells via targeting PTEN.

Bioengineered. 2020-12

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Clin J Gastroenterol. 2020-12

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Therapeutically Significant MicroRNAs in Primary and Metastatic Brain Malignancies.

Cancers (Basel). 2020-9-7

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MicroRNA-140 Represses Esophageal Cancer Progression via Targeting ZEB2 to Regulate Wnt/β-Catenin Pathway.

J Surg Res. 2021-1

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miR-28-5p targets MTSS1 to regulate cell proliferation and apoptosis in esophageal cancer.

Acta Biochim Biophys Sin (Shanghai). 2020-8-5

[7]
Serum exosomal microRNA-766-3p expression is associated with poor prognosis of esophageal squamous cell carcinoma.

Cancer Sci. 2020-8-13

[8]
MicroRNA-155 acts as a diagnostic and prognostic biomarker for oesophageal squamous cell carcinoma.

Artif Cells Nanomed Biotechnol. 2020-12

[9]
MicroRNA-10b controls the metastasis and proliferation of colorectal cancer cells by regulating Krüppel-like factor 4.

Artif Cells Nanomed Biotechnol. 2019-12

[10]
Increased Expression of MiR-27a and MiR-24-2 in Esophageal Squamous Cell Carcinoma.

J Gastrointest Cancer. 2020-3

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