Haghighi S S, Chehrazi B B, Wagner F C
Department of Neurosurgery, University of California, Davis, Sacramento 95817.
Surg Neurol. 1988 Apr;29(4):293-7. doi: 10.1016/0090-3019(88)90160-7.
The effect of nimodipine on acute spinal cord trauma was studied in cats. Spinal evoked responses (SERs) were abolished after weight drop injury of 100 g-cm. All control animals showed spontaneous recovery of spinal cord function as measured by SERs. Treatment with a moderate intravenous dose of nimodipine resulted in a 32% drop in systemic blood pressure and delay in or failure of spinal cord recovery. We concluded that in this model, nimodipine treatment had deleterious effect on the spinal cord recovery due to the significant associated hypotension. It is likely that marked hypotension in the case of traumatic loss of autoregulation overrides the expected nimodipine-related increase in spinal cord blood flow with resultant additional ischemic damage.
在猫身上研究了尼莫地平对急性脊髓损伤的影响。在100克 - 厘米重物坠落损伤后，脊髓诱发电位（SERs）消失。所有对照动物的脊髓功能通过SERs测量显示出自发性恢复。中等静脉剂量的尼莫地平治疗导致全身血压下降32%，脊髓恢复延迟或未能恢复。我们得出结论，在该模型中，由于显著的相关低血压，尼莫地平治疗对脊髓恢复有有害影响。在创伤性自动调节丧失的情况下，明显的低血压可能会超过预期的尼莫地平相关的脊髓血流增加，从而导致额外的缺血性损伤。
