Haghighi S S, Stiens T, Oro J J, Madsen R
Division of Neurosurgery and Medical Statistics, University of Missouri, Columbia.
Surg Neurol. 1993 May;39(5):403-8. doi: 10.1016/0090-3019(93)90209-j.
The cortical somatosensory evoked potentials (CSEPs) were recorded to determine if the administration of nimodipine improves axonal function after spinal cord injury. Animals receiving a 52 g compression injury (a moderately severe injury) for 5 minutes were randomly allocated to one of five treatment groups. Each group was given an infusion of one of the following nimodipine regiments over 2 hours, commencing 1 hour before compression: placebo (n = 20), 0.5 micrograms/kg (n = 10), 0.25 micrograms/kg (n = 20), 0.125 micrograms/kg (n = 10), and 0.25 micrograms/kg + Hetstarch (n = 10). In the control group, 65% of animals lost the CSEPs immediately after the injury with almost all (95%) of these regaining the CSEPs within 15 minutes after decompression of the spinal cord. In the treated groups, the rate of the CSEP loss was highest in the 0.5 micrograms/kg group. This group also had the lowest CSEP recovery. The proportion of the CSEP loss was essentially the same for the other nimodipine-treated groups, although it seemed that there was an increasing number of nonresponses with increasing the nimodipine dose. Our data indicate lack of any beneficial effects of nimodipine on axonal function as measured by evoked activities in experimental spinal cord injury.
记录皮质体感诱发电位（CSEPs）以确定尼莫地平给药是否能改善脊髓损伤后的轴突功能。对接受52 g压迫损伤（中度严重损伤）5分钟的动物随机分配到五个治疗组之一。在压迫前1小时开始，每组在2小时内输注以下尼莫地平方案之一：安慰剂（n = 20）、0.5微克/千克（n = 10）、0.25微克/千克（n = 20）、0.125微克/千克（n = 10）和0.25微克/千克+贺斯（n = 10）。在对照组中，65%的动物在损伤后立即失去CSEPs，几乎所有这些动物（95%）在脊髓减压后15分钟内恢复CSEPs。在治疗组中，0.5微克/千克组CSEP丧失率最高。该组CSEP恢复率也最低。其他尼莫地平治疗组CSEP丧失比例基本相同，尽管似乎随着尼莫地平剂量增加无反应的数量增多。我们的数据表明，在实验性脊髓损伤中，以诱发电活动衡量，尼莫地平对轴突功能没有任何有益作用。
