Laboratory of Biomedical Engineering for Cancer, Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai, Miyagi 980-8575, Japan; Biomedical Engineering Cancer Research Center, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai, Miyagi 980-8575, Japan; Department of Immunology, Kindai University Faculty of Medicine, Osaka-Sayama, Osaka 589-8511, Japan.
Laboratory of Biomedical Engineering for Cancer, Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai, Miyagi 980-8575, Japan; Biomedical Engineering Cancer Research Center, Graduate School of Biomedical Engineering, Tohoku University, 4-1 Seiryo, Aoba, Sendai, Miyagi 980-8575, Japan.
Int J Pharm. 2021 Mar 15;597:120324. doi: 10.1016/j.ijpharm.2021.120324. Epub 2021 Feb 2.
Conventional treatment for lymph node (LN) metastasis such as systemic chemotherapy have notable disadvantages that lead to the development of unwanted effects. Previously, we have reported the lymphatic administration of drugs into metastatic LNs using a lymphatic drug delivery system (LDDS). However, prior studies of the LDDS have not attempted to optimize the conditions for efficient drug delivery. Here, we investigated the influence of several factors on the efficiency of drug delivery by a LDDS in conjunction with ultrasound (US). First, the effect of the injection rate on delivery efficiency was evaluated. Fluorescent molecules injected into an upstream LN were delivered more effectively into a downstream LN when a lower injection rate was used. Second, the influence of molecular weight on drug delivery efficiency was determined. We found that molecules with a molecular weight >10,000 were poorly delivered into the LN. Finally, we assessed whether the administration route affected the delivery efficiency. We found that the delivery efficiency was higher when molecules were administered into an upstream LN that was close to the target LN. These findings revealed the importance of a drug's physical properties if it is to be administered by LDDS to treat LN metastasis.
传统的治疗淋巴结（LN）转移的方法，如全身化疗，有明显的缺点，会导致不良反应的发生。之前，我们已经报道了使用淋巴药物递送系统（LDDS）将药物递送到转移性 LN 中的淋巴给药。然而，之前的 LDDS 研究并没有试图优化高效药物输送的条件。在这里，我们结合超声（US）研究了几种因素对 LDDS 药物输送效率的影响。首先，评估了注射速率对输送效率的影响。当使用较低的注射速率时，注射到上游 LN 的荧光分子更有效地输送到下游 LN。其次，确定了分子量对药物输送效率的影响。我们发现分子量>10000 的分子输送到 LN 的效果较差。最后，我们评估了给药途径是否会影响输送效率。我们发现当分子被递送到靠近靶 LN 的上游 LN 时，输送效率更高。这些发现揭示了如果要通过 LDDS 治疗 LN 转移，药物的物理性质对药物的重要性。
J Biophotonics. 2018-8
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