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[糖尿病肾病患者慢性血液透析治疗的结果]

[Results of chronic hemodialysis treatment in patients with diabetic nephropathy].

作者信息

Watschinger B H, Kührer I, Mayer G, Graf H

机构信息

II. Medizinische Universitätsklinik, Wien.

出版信息

Wien Klin Wochenschr. 1988 Feb 5;100(3):78-82.

PMID:3354218
Abstract

In order to evaluate the differences in morbidity and mortality of diabetics on haemodialysis (HD), data on 12 patients with diabetic nephropathy and 14 non-diabetic patients have been analyzed retrospectively since 1982. The groups were matched for sex, age and duration of HD. We analyzed the differences in survival rate, the number of hospitalization days and the causes of death. Values of BUN, creatinine, calcium, phosphate, cholesterol and triglycerides, alkaline phosphatase, erythrocyte count and haemoglobin were compared throughout the dialysis period. No significant differences occurred between the two groups as regards blood chemistry values (except for creatinine) throughout the observation period. The number of hospitalization days per month of dialysis was significantly different: 1.8 days in diabetic versus 0.9 days in non-diabetic patients (p less than 0.005). This difference is due to a higher rate of vascular access complications and infections. The 3-year survival rate on HD was 73% in type I diabetics (controls 93%), while none of the type II diabetics survived for more than 24 months on HD. The most common causes of death in the diabetic patients were cardiovascular (44%) and septic (44%) complications, followed by cerebrovascular problems (12%). We conclude from our study that the reason for the poor prognosis of diabetic patients on HD is not lack of efficiency of the procedure, but progression of the multisystemic diabetic condition.

摘要

为了评估糖尿病患者血液透析(HD)的发病率和死亡率差异,自1982年以来,我们对12例糖尿病肾病患者和14例非糖尿病患者的数据进行了回顾性分析。两组在性别、年龄和血液透析持续时间方面进行了匹配。我们分析了生存率、住院天数和死亡原因的差异。在整个透析期间,对血尿素氮、肌酐、钙、磷、胆固醇和甘油三酯、碱性磷酸酶、红细胞计数和血红蛋白的值进行了比较。在整个观察期内,两组在血液化学值(除肌酐外)方面没有显著差异。每月透析的住院天数有显著差异:糖尿病患者为1.8天,而非糖尿病患者为0.9天(p<0.005)。这种差异是由于血管通路并发症和感染的发生率较高。I型糖尿病患者血液透析的3年生存率为73%(对照组为93%),而II型糖尿病患者在血液透析中存活超过24个月的无一例。糖尿病患者最常见的死亡原因是心血管并发症(44%)和败血症并发症(44%),其次是脑血管问题(12%)。我们从研究中得出结论,糖尿病患者血液透析预后不良的原因不是该治疗方法缺乏疗效,而是糖尿病多系统病变的进展。

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