Hunan Province Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agro-ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125 Hunan, China.
University of Chinese Academy of Sciences, Beijing 100008, China.
Oxid Med Cell Longev. 2021 Jan 21;2021:8893663. doi: 10.1155/2021/8893663. eCollection 2021.
The gastrointestinal tract (GT) is the major organ involved in digestion, absorption, and immunity, which is prone to oxidative destruction by high levels of reactive oxygen species (ROS) from luminal oxidants, such as food, drugs, and pathogens. Excessive ROS will lead to oxidative stresses and disrupt essential biomolecules, which also act as cellular signaling molecules in response to growth factors, hormones, and oxygen tension changes. Hypoxia-inducible factors (HIFs) are critical regulators mediating responses to cellular oxygen tension changes, which are also involved in energy metabolism, immunity, renewal, and microbial homeostasis in the GT. This review discusses interactions between HIF (mainly HIF-1) and ROS and relevant diseases in the GT combined with our lab's work. It might help to develop new therapies for gastrointestinal diseases associated with ROS and HIF-1.
胃肠道（GT）是主要参与消化、吸收和免疫的器官，易受到来自腔氧化应激物（如食物、药物和病原体）高水平活性氧（ROS）的氧化破坏。过量的 ROS 会导致氧化应激，破坏重要的生物分子，这些生物分子也作为细胞信号分子，响应生长因子、激素和氧张力变化。缺氧诱导因子（HIFs）是调节细胞对氧张力变化反应的关键调节剂，也参与 GT 中的能量代谢、免疫、更新和微生物动态平衡。本综述结合我们实验室的工作，讨论了 HIF（主要是 HIF-1）与 ROS 之间的相互作用以及在 GT 中的相关疾病。这可能有助于为与 ROS 和 HIF-1 相关的胃肠道疾病开发新的治疗方法。
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