Peralta Suarez Geraldine, Deng David W, Silva Raquel, Tinoco Gabriel
Internal Medicine, Universidad Militar Nueva Granada, Bogota, COL.
Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, USA.
Cureus. 2021 Jan 2;13(1):e12432. doi: 10.7759/cureus.12432.
Guillain-Barre syndrome (GBS) is a clinical syndrome with multiple variants. GBS is defined as an acute demyelinating polyneuropathy commonly preceded by infection (bacterial or viral), trauma, or inflammatory processes, which triggers an autoimmune response that affects the peripheral nervous system. This case report describes a patient with high-grade osteosarcoma that completed neoadjuvant chemotherapy and underwent surgical resection with no immediate complications. Fourteen days after the surgery, the patient developed an acute inflammatory demyelinating polyradiculopathy consistent with GBS. As the five-year survival without chemotherapy is only around 20%, this challenging clinical scenario raised questions regarding adjuvant chemotherapy's safe completion in this setting.
格林-巴利综合征（GBS）是一种具有多种变体的临床综合征。GBS被定义为一种急性脱髓鞘性多发性神经病，通常在感染（细菌或病毒）、创伤或炎症过程之前发生，这些因素会引发影响周围神经系统的自身免疫反应。本病例报告描述了一名患有高级别骨肉瘤的患者，该患者完成了新辅助化疗并接受了手术切除，术后无即刻并发症。术后14天，患者出现了与GBS一致的急性炎症性脱髓鞘性多发性神经根病。由于未经化疗的五年生存率仅约为20%，这种具有挑战性的临床情况引发了关于在此情况下辅助化疗能否安全完成的问题。
