Thornton Nicholas J, Garcia Benjamin A, Hoyer Paige, Wilkerson Michael G
Dermatology, University of Texas Medical Branch, Galveston, USA.
Cureus. 2021 Jan 30;13(1):e12999. doi: 10.7759/cureus.12999.
Keloid scars are a common yet poorly understood complication of wound healing that can cause a diminished quality of life. Currently, there is little agreement amongst the medical community regarding the best treatment modality for keloids. For this reason, we have created an updated review of the most successful combination therapies for keloid scars and compared their efficacy based on rates of recurrence following treatment. Additionally, these combination therapies have been compared with intralesional triamcinolone acetonide corticosteroid (TAC), which is considered the mainstay monotherapy for keloids. All combination therapies included in our review were shown to produce superior outcomes than TAC monotherapy. We have also found that certain combination therapies are known to produce superior results when used in specific anatomic locations. Intralesional TAC plus intralesional cryotherapy appeared to have the most promising results for non-auricular keloids, and the authors suggest considering this as a first-line treatment. Additionally, the use of surgical excision plus compression therapy achieved superior results for auricular keloids and should be considered first-line for keloids in these locations.
瘢痕疙瘩是伤口愈合常见但了解甚少的并发症，会导致生活质量下降。目前，医学界对于瘢痕疙瘩的最佳治疗方式几乎没有共识。因此，我们对瘢痕疙瘩最成功的联合治疗方法进行了最新综述，并根据治疗后的复发率比较了它们的疗效。此外，还将这些联合治疗方法与曲安奈德皮质类固醇（TAC）进行了比较，TAC被认为是瘢痕疙瘩的主要单一疗法。我们综述中纳入的所有联合治疗方法均显示出比TAC单一疗法更好的效果。我们还发现，某些联合治疗方法在特定解剖部位使用时效果更佳。病灶内注射TAC加病灶内冷冻疗法对非耳部瘢痕疙瘩似乎有最有前景的结果，作者建议将其作为一线治疗方法。此外，手术切除加压迫疗法对耳部瘢痕疙瘩取得了更好的效果，应被视为这些部位瘢痕疙瘩的一线治疗方法。
