• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

相似文献

1
A Review of Current Keloid Management: Mainstay Monotherapies and Emerging Approaches.瘢痕疙瘩当前治疗方法综述:主流单一疗法及新兴方法
Dermatol Ther (Heidelb). 2020 Oct;10(5):931-948. doi: 10.1007/s13555-020-00427-2. Epub 2020 Jul 23.
2
Intralesional cryotherapy with triamcinolone and onabotulinumtoxinA injections for umbilical keloid: A case report.曲安奈德病灶内冷冻疗法联合A型肉毒毒素注射治疗脐部瘢痕疙瘩:1例报告
Scars Burn Heal. 2021 Dec 21;7:20595131211049040. doi: 10.1177/20595131211049040. eCollection 2021 Jan-Dec.
3
Novel targets and therapies for keloid.瘢痕疙瘩的新型靶点与治疗方法
Clin Exp Dermatol. 2022 Mar;47(3):507-515. doi: 10.1111/ced.14920. Epub 2021 Oct 10.
4
Auricular keloid management in Asian skin: Clinical outcome of intralesional excision and postoperative triamcinolone acetonide intralesional injection.亚洲人皮肤耳郭瘢痕疙瘩的治疗:病损内切除联合术后曲安奈德病损内注射的临床疗效
J Cosmet Dermatol. 2020 Nov;19(11):3041-3047. doi: 10.1111/jocd.13383. Epub 2020 Apr 16.
5
Intralesional cryotherapy versus excision with corticosteroid injections or brachytherapy for keloid treatment: Randomised controlled trials.瘢痕疙瘩治疗中病灶内冷冻疗法与联合皮质类固醇注射的切除术或近距离放射疗法的比较:随机对照试验
J Plast Reconstr Aesthet Surg. 2018 Jun;71(6):847-856. doi: 10.1016/j.bjps.2018.01.033. Epub 2018 Feb 6.
6
Keloids: Current and emerging therapies.瘢痕疙瘩:当前及新兴疗法
Scars Burn Heal. 2020 Aug 10;6:2059513120940499. doi: 10.1177/2059513120940499. eCollection 2020 Jan-Dec.
7
Management of keloids and hypertrophic scars.瘢痕疙瘩和增生性瘢痕的管理。
Am Fam Physician. 2009 Aug 1;80(3):253-60.
8
Treatment of Small Keloids Using Intralesional 5-fluorouracil and Triamcinolone Acetonide versus Intralesional Bleomycin and Triamcinolone Acetonide.病灶内注射5-氟尿嘧啶与曲安奈德对比病灶内注射博来霉素与曲安奈德治疗小瘢痕疙瘩
J Clin Aesthet Dermatol. 2021 Mar;14(3):17-21. Epub 2021 Mar 1.
9
Strontium-90 brachytherapy following intralesional triamcinolone and 5-fluorouracil injections for keloid treatment: A randomized controlled trial.病灶内注射曲安奈德和5-氟尿嘧啶后锶-90近距离放射疗法治疗瘢痕疙瘩:一项随机对照试验。
PLoS One. 2021 Mar 23;16(3):e0248799. doi: 10.1371/journal.pone.0248799. eCollection 2021.
10
Intralesional triamcinolone alone or in combination with botulinium toxin A is ineffective for the treatment of formed keloid scar: A double blind controlled pilot study.单纯病灶内曲安奈德注射或联合肉毒毒素 A 注射治疗增生性瘢痕无效:一项双盲对照的初步研究。
Dermatol Ther. 2019 Mar;32(2):e12781. doi: 10.1111/dth.12781. Epub 2019 Jan 29.

引用本文的文献

1
Retrospective study comparing three approaches for keloids: surgery + radiotherapy, surgery + pharmacological injection, and surgery alone.一项比较瘢痕疙瘩三种治疗方法的回顾性研究:手术+放疗、手术+药物注射和单纯手术。
BMC Surg. 2025 Aug 23;25(1):386. doi: 10.1186/s12893-025-03095-1.
2
Combining Steroid Plus 5-Fluorouracil Injection with Radiotherapy Versus Injection Alone for Keloids: A 4-Year Retrospective Study.类固醇联合5-氟尿嘧啶注射液与单纯注射治疗瘢痕疙瘩的疗效比较:一项4年回顾性研究
Aesthetic Plast Surg. 2025 May 27. doi: 10.1007/s00266-025-04927-4.
3
The Relationship Between Preoperative Vitamin D Levels and Keloid Recurrence.术前维生素D水平与瘢痕疙瘩复发之间的关系
J Cosmet Dermatol. 2025 Feb;24(2):e16687. doi: 10.1111/jocd.16687. Epub 2024 Nov 28.
4
Balloon dilatation followed by triamcinolone acetonide injection for colostomy stenosis: A case report.球囊扩张联合曲安奈德注射治疗结肠造口狭窄:1例报告
Int J Surg Case Rep. 2024 Aug;121:110056. doi: 10.1016/j.ijscr.2024.110056. Epub 2024 Jul 17.
5
Selective therapy (cryo or scalpel) combined with multimodal therapy for treating keloids.采用选择性治疗(冷冻或手术刀切除)联合多模式治疗瘢痕疙瘩。
J Cutan Aesthet Surg. 2024 Apr-Jun;17(2):85-93. doi: 10.4103/JCAS.JCAS_40_23.
6
Pharmacotherapy for Keloids and Hypertrophic Scars.瘢痕疙瘩和增生性瘢痕的药物治疗。
Int J Mol Sci. 2024 Apr 25;25(9):4674. doi: 10.3390/ijms25094674.
7
A randomised clinical trial study assessing the efficacy of 5% losartan potassium loaded in ethosomal gel to treat human keloids: a trial protocol.一项评估 5% 洛沙坦钾载入醇质体凝胶治疗人类瘢痕疙瘩疗效的随机临床试验研究:试验方案。
Trials. 2024 Jan 2;25(1):12. doi: 10.1186/s13063-023-07880-2.
8
Advances and future directions in keloid research: Pathogenesis, diagnosis and personalized treatment strategies.瘢痕疙瘩研究的进展与未来方向:发病机制、诊断及个性化治疗策略
World J Clin Cases. 2023 Dec 6;11(34):8094-8098. doi: 10.12998/wjcc.v11.i34.8094.
9
Efficacy of a multimodal approach of laser therapy for earlobe keloids management in dark population.激光治疗联合多种方法治疗深色人种耳垂瘢痕疙瘩的疗效。
Skin Res Technol. 2023 Nov;29(11):e13502. doi: 10.1111/srt.13502.
10
The Communication from Immune Cells to the Fibroblasts in Keloids: Implications for Immunotherapy.免疫细胞向瘢痕疙瘩成纤维细胞的通讯:免疫治疗的意义。
Int J Mol Sci. 2023 Oct 23;24(20):15475. doi: 10.3390/ijms242015475.

本文引用的文献

1
Combining micro-plasma radio-frequency with hypofractionated electron-beam radiation as a novel treatment of keloids: A case series.微等离子体射频联合低分割电子束辐射治疗瘢痕疙瘩的新方法:病例系列
Medicine (Baltimore). 2019 Nov;98(48):e18094. doi: 10.1097/MD.0000000000018094.
2
A Novel Radiotherapy Approach for Keloids with Intrabeam.腔内近距离放射治疗瘢痕疙瘩的新方法。
Biomed Res Int. 2019 Jul 22;2019:4693528. doi: 10.1155/2019/4693528. eCollection 2019.
3
Intralesional Injection of Botulinum Toxin Type A Compared with Intralesional Injection of Corticosteroid for the Treatment of Hypertrophic Scar and Keloid: A Systematic Review and Meta-Analysis.A型肉毒毒素皮损内注射与皮质类固醇皮损内注射治疗增生性瘢痕和瘢痕疙瘩的疗效比较:系统评价和荟萃分析。
Med Sci Monit. 2019 Apr 22;25:2950-2958. doi: 10.12659/MSM.916305.
4
The Efficacy of Combining Fractional Carbon Dioxide Laser With Verapamil Hydrochloride or 5-Fluorouracil in the Treatment of Hypertrophic Scars and Keloids: A Clinical and Immunohistochemical Study.二氧化碳点阵激光联合盐酸维拉帕米或5-氟尿嘧啶治疗增生性瘢痕和瘢痕疙瘩的疗效:一项临床及免疫组化研究
Dermatol Surg. 2019 Apr;45(4):536-546. doi: 10.1097/DSS.0000000000001726.
5
Combined Therapeutic Strategies for Keloid Treatment.瘢痕疙瘩治疗的联合治疗策略。
Dermatol Surg. 2019 Jun;45(6):802-810. doi: 10.1097/DSS.0000000000001695.
6
Treatment of Keloid Scars with Botulinum Toxin Type A versus Triamcinolone in an Athymic Nude Mouse Model.A型肉毒毒素与曲安奈德治疗无毛小鼠瘢痕疙瘩的比较。
Plast Reconstr Surg. 2019 Mar;143(3):760-767. doi: 10.1097/PRS.0000000000005323.
7
Intralesional triamcinolone alone or in combination with botulinium toxin A is ineffective for the treatment of formed keloid scar: A double blind controlled pilot study.单纯病灶内曲安奈德注射或联合肉毒毒素 A 注射治疗增生性瘢痕无效:一项双盲对照的初步研究。
Dermatol Ther. 2019 Mar;32(2):e12781. doi: 10.1111/dth.12781. Epub 2019 Jan 29.
8
A comparative study of various modalities in the treatment of keloids.各种方法治疗瘢痕疙瘩的对比研究。
Int J Dermatol. 2018 Oct;57(10):1192-1200. doi: 10.1111/ijd.14069. Epub 2018 Jul 11.
9
Comparison of intralesional verapamil versus intralesional corticosteroids in treatment of keloids and hypertrophic scars: A randomized controlled trial.病灶内注射维拉帕米与病灶内注射皮质类固醇治疗瘢痕疙瘩和增生性瘢痕的比较:一项随机对照试验。
Burns. 2018 Sep;44(6):1482-1488. doi: 10.1016/j.burns.2018.05.005. Epub 2018 Jun 7.
10
Steroid tape: A promising adjunct to scar management.类固醇胶带:瘢痕管理的一种有前景的辅助手段。
Scars Burn Heal. 2017 Mar 7;3:2059513117690937. doi: 10.1177/2059513117690937. eCollection 2017 Jan-Dec.

瘢痕疙瘩当前治疗方法综述:主流单一疗法及新兴方法

A Review of Current Keloid Management: Mainstay Monotherapies and Emerging Approaches.

作者信息

Limmer Emily E, Glass Donald A

机构信息

Department of Dermatology, UT Southwestern Medical Center, Dallas, TX, USA.

出版信息

Dermatol Ther (Heidelb). 2020 Oct;10(5):931-948. doi: 10.1007/s13555-020-00427-2. Epub 2020 Jul 23.

DOI:10.1007/s13555-020-00427-2
PMID:32705533
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7477022/
Abstract

Commonly affecting those with skin of color, keloids are an aberrant wound response that leads to wound tissue expanding above and beyond the original cutaneous injury. Keloids are notoriously and particularly difficult to treat because of their tendency to recur after excision. The current standard of care is intralesional steroid (triamcinolone acetonide). However, because no therapy has yet proven to be fully curative, keloid treatments have expanded to include a number of options, from injections to multimodal approaches. This review details current treatment of keloids with injections (bleomycin, verapamil, hyaluronic acid and hyaluronidase, botulinum toxin, and collagenase), cryotherapy, laser, radiofrequency ablation, radiation, extracorporeal shockwave therapy, pentoxifylline, and dupilumab.

摘要

瘢痕疙瘩通常影响有色人种,是一种异常的伤口反应,导致伤口组织在原始皮肤损伤之上及之外扩张。瘢痕疙瘩因其切除后易复发而 notoriously 且特别难以治疗。目前的护理标准是病灶内注射类固醇(曲安奈德)。然而,由于尚无疗法被证明能完全治愈,瘢痕疙瘩的治疗已扩展到包括多种选择,从注射到多模式方法。本综述详细介绍了目前用注射剂(博来霉素、维拉帕米、透明质酸和透明质酸酶、肉毒杆菌毒素和胶原酶)、冷冻疗法、激光、射频消融、放射、体外冲击波疗法、己酮可可碱和度普利尤单抗治疗瘢痕疙瘩的情况。