Limmer Emily E, Glass Donald A
Department of Dermatology, UT Southwestern Medical Center, Dallas, TX, USA.
Dermatol Ther (Heidelb). 2020 Oct;10(5):931-948. doi: 10.1007/s13555-020-00427-2. Epub 2020 Jul 23.
Commonly affecting those with skin of color, keloids are an aberrant wound response that leads to wound tissue expanding above and beyond the original cutaneous injury. Keloids are notoriously and particularly difficult to treat because of their tendency to recur after excision. The current standard of care is intralesional steroid (triamcinolone acetonide). However, because no therapy has yet proven to be fully curative, keloid treatments have expanded to include a number of options, from injections to multimodal approaches. This review details current treatment of keloids with injections (bleomycin, verapamil, hyaluronic acid and hyaluronidase, botulinum toxin, and collagenase), cryotherapy, laser, radiofrequency ablation, radiation, extracorporeal shockwave therapy, pentoxifylline, and dupilumab.
瘢痕疙瘩通常影响有色人种,是一种异常的伤口反应,导致伤口组织在原始皮肤损伤之上及之外扩张。瘢痕疙瘩因其切除后易复发而 notoriously 且特别难以治疗。目前的护理标准是病灶内注射类固醇(曲安奈德)。然而,由于尚无疗法被证明能完全治愈,瘢痕疙瘩的治疗已扩展到包括多种选择,从注射到多模式方法。本综述详细介绍了目前用注射剂(博来霉素、维拉帕米、透明质酸和透明质酸酶、肉毒杆菌毒素和胶原酶)、冷冻疗法、激光、射频消融、放射、体外冲击波疗法、己酮可可碱和度普利尤单抗治疗瘢痕疙瘩的情况。