垂体疾病：最新进展。
Pituitary disease: An update.
作者信息
Inder Warrick J, Jang Christina
机构信息
MBChB, MD, FRACP, Endocrinologist, Department of Diabetes and Endocrinology, Princess Alexandra Hospital, Qld; Associate Professor, Faculty of Medicine, The University of Queensland, Qld.
MBBS, MD, FRACP, Senior Lecturer, Faculty of Medicine, The University of Queensland, Qld; Endocrinologist, Queensland Diabetes and Endocrine Centre, Mater Health, Qld.
出版信息
Aust J Gen Pract. 2021 Jan-Feb;50(1-2):30-35. doi: 10.31128/AJGP-10-20-5688.
BACKGROUND
Pituitary lesions are present in >10% of the population. Approximately one in 1000 people has a symptomatic pituitary tumour, which may cause clinical problems from mass effect, hormonal hypersecretion and impairment of normal pituitary function.
OBJECTIVE
The aim of this article is to outline the potential causes of a sellar and parasellar mass, with an emphasis on the presenting clinical features and screening investigations that are applicable to doctors working in the primary care setting.
DISCUSSION
There is a broad range of causes of a sellar/parasellar mass. Pituitary adenomas and Rathke's cleft cysts are the most frequently encountered. Prolactinomas are the most common functioning tumour and tend to present as macroadenomas in men, while hyperprolactinaemia is associated with 15% of secondary amenorrhoea in women. Acromegaly and Cushing's disease are rare but important diagnoses to detect. Pituitary disease is optimally managed in a specialist centre in the context of an established multidisciplinary team.
背景
垂体病变在超过10%的人群中存在。每1000人中约有1人患有有症状的垂体肿瘤，这可能因占位效应、激素分泌过多及正常垂体功能受损而引发临床问题。
目的
本文旨在概述鞍区及鞍旁肿物的潜在病因，重点关注适用于基层医疗工作医生的临床表现及筛查检查。
讨论
鞍区/鞍旁肿物病因广泛。垂体腺瘤和拉克氏囊肿最为常见。催乳素瘤是最常见的功能性肿瘤，在男性中多表现为大腺瘤，而高催乳素血症与女性15%的继发性闭经有关。肢端肥大症和库欣病虽罕见但为重要的可检测诊断。垂体疾病在成熟的多学科团队背景下，于专科中心进行最佳管理。
Zotero 插件