State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China.
Dalton Trans. 2021 Feb 14;50(6):2014-2017. doi: 10.1039/d0dt03734f. Epub 2021 Feb 5.
pH is a critical parameter that has found unique application in magnetic resonance imaging (MRI) mapping acidity in tissues. This study reports a series of Dy-based MR probes that show innovative T features, governed by proton catalyzed events. With an increase of pH from 5.5 to 8.0, the r relaxivity increased dramatically, while the r relaxivity remained unchanged. The resulting r/r allowed for concentration-independent and direct mapping of physiologically relevant pH ranges.
pH 值是一个关键参数，在磁共振成像（MRI）中用于组织酸度的mapping 方面具有独特的应用。本研究报道了一系列基于 Dy 的 MR 探针，这些探针具有创新的 T 特性，由质子催化事件控制。随着 pH 值从 5.5 增加到 8.0，r1 弛豫率显著增加，而 r1 弛豫率保持不变。所得的 r/r 允许进行与浓度无关的、直接的生理相关 pH 范围 mapping。
