Scardi S, Pandullo C, Pivotti F, Ceschia G, Pollavini G
Centro Cardiovascolare, Ospedale Maggiore, Trieste, Italy.
Am J Cardiol. 1988 Apr 1;61(10):691-5. doi: 10.1016/0002-9149(88)91050-8.
To investigate the antianginal efficacy, duration of action and tolerability of 2 doses of the new calcium antagonist felodipine, 15 patients (14 men and 1 woman, mean age 62 years) with stable exertional angina pectoris and angiographically demonstrated coronary artery disease were randomly given felodipine, 5 and 10 mg, and placebo on 3 different days. A bicycle ergometer exercise test was performed 3 and 10 hours after dosing. In comparison with placebo, felodipine 5 and 10 mg significantly increased resting heart rate and decreased resting systolic and diastolic blood pressure 3 hours after administration (p less than 0.001). Ten hours after administration, only supine systolic blood pressure was still significantly lower (p less than 0.001). Anginal (time to mild chest pain) and ischemic (time to 1 mm ST depression) thresholds, as well as duration of exercise and total work at peak exercise, were higher in comparison with placebo at 3 and 10 hours (p less than 0.001). In comparison with the lower dose, 10 mg felodipine induced a decrease in supine (p less than 0.05) and sitting (p less than 0.01) systolic blood pressure at rest and an increase in total work to anginal threshold (p less than 0.01), as well as in total work and duration of exercise at peak exercise (p less than 0.05). These results suggest that a single administration of felodipine, 5 and 10 mg, may improve exercise capacity over a 10-hour period in patients with stable exercise-induced angina due to atherosclerotic heart disease.
为研究两种剂量的新型钙拮抗剂非洛地平的抗心绞痛疗效、作用持续时间和耐受性，15例（14例男性，1例女性，平均年龄62岁）患有稳定劳力型心绞痛且经血管造影证实有冠状动脉疾病的患者在3个不同日期随机服用5毫克和10毫克非洛地平以及安慰剂。给药后3小时和10小时进行自行车测力计运动试验。与安慰剂相比，服用5毫克和10毫克非洛地平后3小时静息心率显著增加，静息收缩压和舒张压显著降低（p<0.001）。给药10小时后，仅仰卧位收缩压仍显著较低（p<0.001）。与安慰剂相比，在3小时和10小时时，心绞痛（轻度胸痛发作时间）和缺血（ST段压低1毫米的时间）阈值以及运动持续时间和运动峰值时的总功均更高（p<0.001）。与低剂量相比，10毫克非洛地平使静息时仰卧位（p<0.05）和坐位（p<0.01）收缩压降低，心绞痛阈值时的总功增加（p<0.01），以及运动峰值时的总功和运动持续时间增加（p<0.05）。这些结果表明，单次服用5毫克和10毫克非洛地平可能在10小时内改善因动脉粥样硬化性心脏病导致的稳定运动诱发型心绞痛患者的运动能力。
