Department of Oral Pathology and Microbiology, Post Graduate Institute of Dental Sciences, Pt.BD. Sharma University, Rohtak, Haryana, India.
Department of Pathology, Post Graduate Institute of Medical Sciences, Pt.BD. Sharma University, Rohtak, Haryana, India.
Head Neck Pathol. 2021 Sep;15(3):831-842. doi: 10.1007/s12105-021-01291-y. Epub 2021 Feb 5.
MUC1 and MUC4 are two transmembranous proteins, which have been seen to express aberrantly in various human neoplasms and advocated as independent prognostic markers. Till now no extensive studies have been carried out on combined expression of MUC1 and MUC4 in oral leukoplakia and Oral squamous cell carcinoma. This study is an endeavour to evaluate Immunohistochemical coexpression of MUC1 and MUC4 in Oral Leukoplakia and Oral squamous cell carcinoma and furthr establish them as prognostic markers. Immunohistochemical analysis of MUC1 and MUC4 was done on 24 cases of Oral squamous cell carcinoma, 24 cases of leukoplakia and 12 normal oral mucosal tissues. Chi square test and one way ANOVA test were employed for statistical analysis. Normal oral mucosa and leukoplakia group showed higher frequency of negative immunoexpression compared to oral squamous cell carcinoma group. Furthur in Oral squamous cell carcinoma group, higher frequency of double positive coexpression in well and moderately differentiated oral squamous cell carcinoma and single positive coexpression in poorly differentiated oral squamous cell carcinoma was obtained. A definite rise of immunoexpression of MUC1 and MUC4 was observed from normal oral mucosa to leukoplakia to oral squamous cell carcinoma indicative of their contribution as diagnostic and prognostic markers.
MUC1 和 MUC4 是两种跨膜蛋白，已在各种人类肿瘤中观察到异常表达，并被认为是独立的预后标志物。到目前为止，尚未对口腔白斑病和口腔鳞状细胞癌中 MUC1 和 MUC4 的联合表达进行广泛研究。本研究旨在评估 MUC1 和 MUC4 在口腔白斑病和口腔鳞状细胞癌中的免疫组织化学共表达，并进一步将其确立为预后标志物。对 24 例口腔鳞状细胞癌、24 例白斑病和 12 例正常口腔黏膜组织进行了 MUC1 和 MUC4 的免疫组织化学分析。采用卡方检验和单因素方差分析进行统计学分析。与口腔鳞状细胞癌组相比，正常口腔黏膜和白斑病组的阴性免疫表达频率更高。在口腔鳞状细胞癌组中，在分化良好和中度分化的口腔鳞状细胞癌中观察到双阳性共表达的频率较高，而在分化不良的口腔鳞状细胞癌中观察到单阳性共表达的频率较高。从正常口腔黏膜到白斑病再到口腔鳞状细胞癌，观察到 MUC1 和 MUC4 的免疫表达明显升高，表明它们作为诊断和预后标志物的作用。
